Comparison of Beta-2 Adrenergic Receptor Gene Polymorphisms Between Patients With Fibromyalgia Syndrome and Healthy Controls

Objectives: This study aims to compare the beta-2 adrenergic receptor (ADRB2) gene polymorphisms of patients with fibromyalgia syndrome (FMS) with those of healthy control subjects, and to investigate the possible relationship between symptoms of FMS and polymorphisms of the ADRB2 gene. Patients and methods: The study included 170 females (mean age 47.8±10.3 years; range, 21 to 75 years) diagnosed with FMS according to the 2010 American College of Rheumatology criteria and 170 healthy females (mean age 47.2±8.8 years; range, 20 to 72 years) as the control group. Several clinical symptoms of the participants related to FMS were questioned and recorded. The visual analog scale (VAS) and Fibromyalgia Impact Questionnaire (FIQ) scores of the fibromyalgia group were recorded. In both groups, the ADRB2 (rs1042717) single-nucleotide polymorphism was detected by way of a real-time polymerase chain reaction. The wild-type (Guanine/Guanine), the mutant type (Adenine/Adenine) and heterozygous type (Adenine/Guanine) were detected. The sample power was calculated considering the minor allele frequency. Results: The comparison of the ADRB2 gene polymorphism between patients with FMS and the control subjects showed that the groups were similar in terms of ADBR2 gene polymorphism and genotype (p>0.05). There was no significant difference in terms of genotype when the ADRB2 gene polymorphisms in patients with FMS were compared in terms of clinical symptoms, VAS and FIQ scores (p>0.05). Conclusion: Beta-2 adrenergic receptor (rs1042717) gene polymorphisms and genotype distribution are no different between patients with FMS and healthy individuals. ADRB2 gene polymorphisms in patients with FMS have no effect on clinical symptoms and VAS and FIQ scores. The results of the present study will light the way for future research into ADRB2 gene polymorphisms in the pathogenesis of FMS.

Kaynakça

Metyas S, Rezk T, Arkfeld D, Leptich T. Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review. Curr Rheumatol Rev 2017;13:98-102.

Dadabhoy D, Clauw DJ. Therapy Insight: fibromyalgia- -a different type of pain needing a different type of treatment. Nat Clin Pract Rheumatol 2006;2:364-72.

Albrecht PJ, Rice FL. Fibromyalgia syndrome pathology and environmental influences on afflictions with medically unexplained symptoms. Rev Environ Health 2016;31:281-94.

Martínez-Lavín M, Hermosillo AG. Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 2000;29:197-9.

Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005;14:135-43.

Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, et al. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat 2012;2012:426130.

Martínez-Martínez LA, Mora T, Vargas A, Fuentes- Iniestra M, Martínez-Lavín M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. J Clin Rheumatol 2014;20:146-50.

Buskila D. Developments in the scientific and clinical understanding of fibromyalgia. Arthritis Res Ther 2009;11:242.

Ablin J, Neumann L, Buskila D. Pathogenesis of fibromyalgia - a review. Joint Bone Spine 2008;75:273-9.

Giacomelli C, Sernissi F, Sarzi-Puttini P, Di Franco M, Atzeni F, Bazzichi L. Fibromyalgia: a critical digest of the recent literature. Clin Exp Rheumatol 2013;31:S153-7.

Gürsoy S, Erdal E, Herken H, Madenci E, Alaehirli B, Erdal N. Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int 2003;23:104-7.

Josep García-Fructuoso F, Ignacio Lao-Villadóniga J, Beyer K, Santos C. Relationship between COMT gene genotypes and severity of fibromyalgia. Reumatol Clin 2006;2:168-72.

Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadóniga JI, et al. Catechol-Omethyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Res Ther 2007;9:R110.

Bozkaya ÖG. Klinisyenler için mutasyon ve polimorfizm. Turkiye Klinikleri J Pediatr 2009;18:47-53.

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001;29:308-11.

Covolo L, Gelatti U, Metra M, Nodari S, Piccichè A, Pezzali N, et al. Role of beta1- and beta2-adrenoceptor polymorphisms in heart failure: a case-control study. Eur Heart J 2004;25:1534-41.

Mohamed-Hussein AAR, Sayed SS, Eldien HMS, Assar AM, Yehia FE. Beta 2 Adrenergic Receptor Genetic Polymorphisms in Bronchial Asthma: Relationship to Disease Risk, Severity, and Treatment Response. Lung 2018;196:673-80.

Feng S, Li N, Xu S, Wang H, Yu W, Lu Y, et al. Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population. Int J Clin Exp Med 2015;8:11514-8.

Hocking LJ, Smith BH, Jones GT, Reid DM, Strachan DP, Macfarlane GJ. Genetic variation in the beta2-adrenergic receptor but not catecholamine-Omethyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study. Pain 2010;149:143-51.

Brodde OE. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol Ther 2008;117:1-29.

Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, et al. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 2006;141B:449-62.

Xiao Y, He W, Russell IJ. Genetic polymorphisms of the beta2-adrenergic receptor relate to guanosine proteincoupled stimulator receptor dysfunction in fibromyalgia syndrome. J Rheumatol 2011;38:1095-103.

Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Martinez A, Lao-Villadóniga JI, et al. Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. Arthritis Rheum 2009;60:2169-73.

Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010;62:600-10.

Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol 1991;18:728-33.

Sarmer S, Ergin S, Yavuzer G. The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int 2000;20:9-12.

Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.

Relethford JH. Hardy-Weinberg equilibrium. In: Cartmill M, Brown K, Relethford JH, editors. Human Population Genetics. 1st ed. New Jersey: John Wiley & Sons; 2012. p. 23-48.

Higgins TJ. Molecular Characterization of b2 Adrenergic Receptor Haplotypes. Thesis (Neurobiyology) University of North Caroline at Chapel Hill, 2008;15-8.

Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W. Idiopathic pain disorders--pathways of vulnerability. Pain 2006;123:226-30.

Diamond S, Solomon GD, Freitag FG, Mehta ND. Long-acting propranolol in the prophylaxis of migraine. Headache 1987;27:70-2.

Wood PB, Kablinger AS, Caldito GS. Open trial of pindolol in the treatment of fibromyalgia. Ann Pharmacother 2005;39:1812-6.

Aley KO, Martin A, McMahon T, Mok J, Levine JD, Messing RO. Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci 2001;21:6933-9.

Khasar SG, McCarter G, Levine JD. Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999;81:1104- 12.

Kaynak Göster

308 121

Arşiv
Sayıdaki Diğer Makaleler

Comparison of Beta-2 Adrenergic Receptor Gene Polymorphisms Between Patients With Fibromyalgia Syndrome and Healthy Controls

Gözde ŞEN ÇAKIROĞLU, Sami HİZMETLİ, YAVUZ SİLİĞ, AHMET KARADAĞ, Emrullah HAYTA, Burcu ÖZALTIN, AYÇA TAŞ, Cemile ZONTUL

Demodex Species Frequency and Risk Factors in Patients With Rheumatoid Arthritis

Hatice YAZISIZ, Yeşim ÇEKİN, İlhan SEZER, Feyzi BOSTAN, Fatma Gülsüm KOÇLAR

The Turkish League Against Rheumatism Recommendations for the Management of Hand Osteoarthritis Under Guidance of the Current Literature and 2018 European League Against Rheumatism Recommendations

Fi̇kri̇ye Fi̇gen AYHAN, İsmihan SUNAR, Ebru UMAY, ESRA DİLEK KESKİN, Lale ALTAN, Fitnat DİNÇER, Tuncay DURUÖZ, Nazım KARALEZLİ, Tiraje TUNCER, KADRİYE BANU KURAN

The Effects of Tofacitinib-Mediated Janus Kinase/Signal Transducers and Activators of the Transcription Signal Pathway Inhibition on Collagen Biosynthesis in Hepatic and Skin Fibroblast Cell Culture

Mehtap ŞAHİN, Hüseyin AYDIN, Ahmet ALTUN, Mehmet Emin DERİN, Ali ŞAHİN

First Reported Mycobacterium Marinum Infection Case in a Patient With Psoriatic Arthritis Maintained on Golimumab

Mohamad Ali RIDA, Tara BARDAWIL, Dima IBRAHIM

Prevalence of Subclinical Carotid Atherosclerosis and Vitamin D Deficiency in Egyptian Ankylosing Spondylitis Patients

Dina Salem FOTOH, Dena Mamdouh SERAG, Ismail Tawfeek BADR, Dalia Salah SAIF

Biomarkers of Cardiovascular Disease in Patients With Ankylosing Spondylitis

Ümit SARP, Evren ÜSTÜNER, Sehim KUTLAY, Şebnem ATAMAN, Sim KUTLAY

Joint Surgery in Tunisian Rheumatoid Arthritis Patients: Prevalence and Risk Factors

Olfa SAIDANE, Leila GAFSI, Aicha BEN TEKAYA, Ines MAHMOUD, Rawdha TEKAYA, Leila ABDELMOULA

The Relationship Between Serum Angiogenic Factor Levels and Disease Activity in Rheumatoid Arthritis

Zahide ASLANALP, Canan TIKIZ, Aslıhan ULUSOY, Şebnem ORGUC, Aysun BİLGİ YEDEKCİ, Cevval ULMAN

Epigenetics in Osteoarthritis Related Pain: An Update

Jorge Hugo VILLAFA E, Paolo PEDERSINI, Pedro BERJANO