An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility

Objectives: This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp insertion of bradykinin receptor 2 gene, (iv) the -58T>C of bradykinin receptor 2 gene, and (v) the -699G>C of bradykinin receptor 1 gene. Patients and methods: The study included 136 RA patients (27 males; 109 females; mean age 60.8 years; range 39 to 75 years) and 149 ethnic matching controls (30 males, 119 females; mean age 56.2 years; range 35 to 78 years). Polymerase chain reaction coupled with restriction assay was performed for 587C>T, -58T>C, and -699G>C. Results: Rheumatoid arthritis patients and controls carried the wild type allele of 587C>T; therefore, produced the high molecular weight kininogen. No significant difference was observed in genotype or allele distribution of the studied functional polymorphisms between RA patients and controls. Conclusion: Kinin-kallikrein system related genes might not be major RA susceptibility loci.

Kaynakça

Bachvarov DR, Landry M, Houle S, Paré P, Marceau F. Altered frequency of a promoter polymorphic allele of the kinin B1 receptor gene in inflammatory bowel disease. Gastroenterology 1998;115:1045-8.

Kusser B, Braun A, Praun M, Illi S, von Mutius E, Roscher AA. Polymorphisms in the bradykinin B2 receptor gene and childhood asthma. Biol Chem 2001;382:885-9.

Tomita H, Sato S, Matsuda R, Ogisu N, Mori T, Niimi T, et al. Genetic polymorphism of the angiotensinconverting enzyme (ACE) in asthmatic patients. Respir Med 1998;92:1305-10.

Benessiano J, Crestani B, Mestari F, Klouche W, Neukirch F, Hacein-Bey S, et al. High frequency of a deletion polymorphism of the angiotensin-converting enzyme gene in asthma. J Allergy Clin Immunol 1997;99:53-7.

Pullmann R Jr, Lukác J, Skerenová M, Rovensky J, Hybenová J, Melus V, et al. Association between systemic lupus erythematosus and insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene. Clin Exp Rheumatol 1999;17:593-6.

Kaufman KM, Kelly J, Gray-McGuire C, Asundi N, Yu H, Reid J, et al. Linkage analysis of angiotensinconverting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus. Mol Cell Endocrinol 2001;177:81-5.

Uhm WS, Lee HS, Chung YH, Kim TH, Bae SC, Joo KB, et al. Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. Lupus 2002;11:227-33.

Alsaeid K, Haider MZ, Ayoub EM. Angiotensin converting enzyme gene insertion-deletion polymorphism is associated with juvenile rheumatoid arthritis. J Rheumatol 2003;30:2705-9.

Carluccio M, Soccio M, De Caterina R. Aspects of gene polymorphisms in cardiovascular disease: the renin-angiotensin system. Eur J Clin Invest 2001;31:476-88.

Sawai K, Niwa S, Katori M. The significant reduction of high molecular weight-kininogen in synovial fluid of patients with active rheumatoid arthritis. Adv Exp Med Biol 1979;120:195-202.

Hernández CC, Donadi EA, Reis ML. Kallikreins and kininogens in saliva and plasma of patients presenting with rheumatoid arthritis. Scand J Rheumatol 2002;31:38-40.

Isordia-Salas I, Pixley RA, Sáinz IM, Martínez-Murillo C, Colman RW. The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation. Arch Med Res 2004;35:369-77.

Sharma JN. Involvement of the kinin-forming system in the physiopathology of rheumatoid inflammation. Agents Actions Suppl 1992;38:343-61.

Okabe T, Yamagata K, Fujisawa M, Watanabe J, Takaku F, Lanzillo JJ, et al. Increased angiotensin-converting enzyme in peripheral blood monocytes from patients with sarcoidosis. J Clin Invest 1985;75:911-4.

Silverstein E, Pertschuk LP, Friedland J. Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc Natl Acad Sci U S A 1979;76:6646-8.

Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum 1990;33:768-73.

Lerner UH, Jones IL, Gustafson GT. Bradykinin, a new potential mediator of inflammation-induced bone resorption. Studies of the effects on mouse calvarial bones and articular cartilage in vitro. Arthritis Rheum 1987;30:530-40.

Weger W, Hofer A, Wolf P, El-Shabrawi Y, Renner W, Kerl H, et al. The angiotensin-converting enzyme insertion/deletion and the endothelin -134 3A/4A gene polymorphisms in patients with chronic plaque psoriasis. Exp Dermatol 2007;16:993-8.

Brechter AB, Lerner UH. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum 2007;56:910-23.

Brechter AB, Persson E, Lundgren I, Lerner UH. Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases. Bone 2008;43:72-83.

Lerner UH, Lundberg P. Kinins and neuro-osteogenic factors, In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. 2nd ed. San Diego: Academic Pres; 2002. p. 773-99.

Lerner UH. The role of the kallikrein-kinin system in inflammation-induced bone metabolism. In: Farmer SG, editor. The kinin system. New York: Academic Press; 1997. p. 219-34.

Knigge H, Blüthner M, Brüntgens A, Sator H, Ritz E. G(-699)/C polymorphism in the bradykinin-1 receptor gene in patients with renal failure. Nephrol Dial Transplant 2000;15:586-8.

Mulatero P, Williams TA, Milan A, Paglieri C, Rabbia F, Fallo F, et al. Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms. J Clin Endocrinol Metab 2002;87:3337-43.

Mukae S, Itoh S, Aoki S, Iwata T, Nishio K, Sato R, et al. Association of polymorphisms of the reninangiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. J Hum Hypertens 2002;16:857-63.

Lee YC, Cheon KT, Lee HB, Kim W, Rhee YK, Kim DS. Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma. Allergy 2000;55:959-63.

Cheung PP, Kunapuli SP, Scott CF, Wachtfogel YT, Colman RW. Genetic basis of total kininogen deficiency in Williams' trait. J Biol Chem 1993;268:23361-5.

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.

Bachvarov DR, Landry M, Pelletier I, Chevrette M, Betard C, Houde I, et al. Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. J Am Soc Nephrol 1998;9:598-604.

Lung CC, Chan EK, Zuraw BL. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol 1997;99:134-46.

Braun A, Kammerer S, Maier E, Böhme E, Roscher AA. Polymorphisms in the gene for the human B2-bradykinin receptor. New tools in assessing a genetic risk for bradykinin-associated diseases. Immunopharmacology 1996;33:32-5.

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6.

Ishimaru F, Dansako H, Nakase K, Fujii N, Sezaki N, Nakayama H, et al. Molecular characterization of total kininogen deficiency in Japanese patients. Int J Hematol 1999;69:126-8.

Dutra RC. Kinin receptors: Key regulators of autoimmunity. Autoimmun Rev 2017;16:192-207.

Uppal SS, Haider MZ, Hayat SJ, Abraham M, Sukumaran J, Dhaunsi GS. Significant association of insertion/deletion polymorphism of the angiotensinconverting enzyme gene with rheumatoid arthritis. J Rheumatol 2007;34:2395-9.

Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med 2007;357:1199-209.

Lequerré T, Gauthier-Jauneau AC, Bansard C, Derambure C, Hiron M, Vittecoq O, et al. Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. Arthritis Res Ther 2006;8:105.

Liu Z, Maas K, Aune TM. Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance. Hum Mol Genet 2006;15:501-9.

Maas K, Chen H, Shyr Y, Olsen NJ, Aune T. Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease. Hum Mol Genet 2005;14:1305-14.

Cassim B, Naidoo S, Ramsaroop R, Bhoola KD. Immunolocalization of bradykinin receptors on human synovial tissue. Immunopharmacology 1997;36:121-5.

Uhl J, Singh S, Brophy L, Faunce D, Sawutz DG. Role of bradykinin in inflammatory arthritis: identification and functional analysis of bradykinin receptors on human synovial fibroblasts. Immunopharmacology 1992;23:131-8.

Selwyn BM, Figueroa CD, Fink E, Swan A, Dieppe PA, Bhoola KD. A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis. Ann Rheum Dis 1989;48:128-33.

Kellermeyer RW, Graham RC Jr. Kinins--possible physiologic and pathologic roles in man. N Engl J Med 1968;279:859-66.

Worthy K, Figueroa CD, Dieppe PA, Bhoola KD. Kallikreins and kinins: mediators in inflammatory joint disease? Int J Exp Pathol 1990;71:587-601.

Veale D, Yanni G, Bresnihan B, FitzGerald O. Production of angiotensin converting enzyme by rheumatoid synovial membrane. Ann Rheum Dis 1992;51:476-80.

Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JC. ACE polymorphisms. Circ Res 2006;98:1123-33.

Marceau F, Regoli D. Bradykinin receptor ligands: therapeutic perspectives. Nat Rev Drug Discov 2004;3:845-52.

Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005;57:27-77.

Marceau F, Hess JF, Bachvarov DR. The B1 receptors for kinins. Pharmacol Rev 1998;50:357-86.

Burch RM, Kyle DJ. Recent developments in the understanding of bradykinin receptors. Life Sci 1992;50:829-38.

Bhoola KD, Figueroa CD, Worthy K. Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev 1992;44:1-80.

Dray A, Perkins M. Bradykinin and inflammatory pain. Trends Neurosci 1993;16:99-104.

Couture R, Harrisson M, Vianna RM, Cloutier F. Kinin receptors in pain and inflammation. Eur J Pharmacol 2001;429:161-76.

FitzGerald O, Soden M, Yanni G, Robinson R, Bresnihan B. Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis. Ann Rheum Dis 1991;50:792-6.

Iguchi T, Ziff M. Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation. J Clin Invest 1986;77:355-61.

Kaynak Göster

  • ISSN: 2148-5046
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2014

3.3b 2.5b

Sayıdaki Diğer Makaleler

Pauci-immune Crescentic Glomerulonephritis in a Patient With Immunoglobulin A Nephropathy and Serum Antineutrophil Cytoplasmic Autoantibody Positivity

Keren COHEN-HAGAI, Sydney BENCHETRIT, Osnat KLEIN, Yona KITAY-COHEN, Zeev KORZETS

Cerebral Blood Flow Volume Using Color Duplex Sonography in Patients With Fibromyalgia Syndrome

ARZU KAYA, GÜRKAN AKGÖL, ARİF GÜLKESEN, AHMET KÜRŞAD POYRAZ, TÜLAY YILDIRIM, MURAD ATMACA

Relationship Between Smoking and Structural Damage, Autoimmune Antibodies, and Disability in Rheumatoid Arthritis Patients

FİLİZ SİVAS, Fatma GÜL YURDAKUL, Ayşegül KILIÇARSLAN, Semra DURAN, Bedriye BAŞKAN, HATİCE BODUR

The Association of Skinfold Anthropometric Measures, Body Composition and Disease Severity in Obese and Non-obese Fibromyalgia Patients: A Cross-sectional Study

Mehmet Onat ÇAKIT, BURCU DUYUR ÇAKIT, HAKAN GENÇ, Seçil Pervane VURAL, HATİCE RANA ERDEM, Meryem SARAÇOĞLU, Aynur KARAGÖZ

Protective Effect of Tetrandrine in a Rabbit Model of Osteoarthritis

Fengfeng WU, Juntao XU, Zaihua ZHU

Comparison of Effects of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pain and Functionality in Patients With Lateral Epicondylitis

Melek YERLİKAYA, HAVVA TALAY ÇALIŞ, Serap Tomruk SÜTBEYAZ, Hatice SAYAN, Nurdan İBİŞ, Ali KOÇ, Çiğdem KARAKÜKCÜ

Depression as the First Manifestation in a Young Girl With Juvenile Systemic Lupus Erythematosus

Tania Caroline MONTEIRO DE CASTRO, Ho Chi HSIEN

Idiopathic Interstitial Pneumonia as a Possible Cause of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

Hiroshi OİWA, Katsuhiro OOI, Tetsu OYAMA, Eiji SUGYAMA

Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease

Di LİU, Wangbin NING, Xiaoxia ZUO

A New Objective Parameter in Hydroxychloroquine-Induced Retinal Toxicity Screening Test: Macular Retinal Ganglion Cell-Inner Plexiform Layer Thickness

Mehmet BULUT, Muhammet Kazım EROL, Devrim TOSLAK, Melih AKIDAN, Ebru KAYA BAŞAR, Hasan Fatih ÇAY