Özge TURGAY YILDIRIM, Ercan AKŞİT, Fatih AYDIN, Ayşe HÜSEYİNOĞLU AYDIN

Hipertansif hastalarda plazma aterojenik indeks düzeylerinin incelenmesi

Amaç: Hipertansiyon, kardiyovasküler sistem için önemli risk faktörlerinden biridir. Son dönemde yapılan araştırmalar, plazma aterojenik indeksinin (PAİ) kardiyovasküler morbidite, tüm nedenlere bağlı ölüm, ateroskleroz ve koroner arter hastalığının ciddiyeti ile güçlü bir ilişkisi olduğu gösterilmiştir. Ayrıca hipertansif hastalarda endotel hasarı ile ilişkisi vardır. Biz bu çalışma ile PAİ ile hipertansiyon arasındaki ilişkiyi araştırmayı amaçladık.Yöntemler: Çalışmaya toplam 213 hasta alındı. Daha önce hipertansiyon, nefrotik sendrom, diyabetes mellitus, hipotiroidizm tanısı olan, statin tedavisi alan ve 18 yaşın altındaki hastalar çalışmadan dışlandı. 24 saatlik ambulatuvar kan basıncı ölçümü ile hipertansiyon tanısı ve kan basıncı (KB) sonuçları alındı. PAİ, trigliseritin yüksek yoğunluklu lipoprotein kolesterol oranının logaritmik dönüşümü olarak tanımlandı.Bulgular: Çalışmaya katılan hastaların yaş ortalaması 49,2 ± 14,6 yıl idi ve % 41,8'ü (n = 89) erkekti. 24 saatlik ambulatuar kan basıncı ölçümü sonuçlarına göre, PAİ, gündüz sistolik kan basıncı (SKB) (r=0,244, p<0,001), gündüz diyastolik kan basıncı (DKB) (r=0,276, p<0,001), gece SBP (r=0,259, p<0,001), gece DKB (r=0,299, p<0,001), ortalama SKB (r=0.213, p=0,002) ve ortalama DKB (r=0,296, p<0,001) ile pozitif olarak korele idi. Hipertansif hastalarda PAİ normotansif hastalara göre istatistiksel olarak anlamlı düzeyde yüksekti (p=0,001). Sonuç: Çalışmamızın sonucunda PAİ'nin kan basıncıyla pozitif olarak korele olduğu ve PAİ değerlerinin hipertansif hastalarda istatistiksel açıdan anlamlı şekilde yüksek olduğunu saptamıştır.

Anahtar Kelimeler:

Plazma aterojenik indeksi, hipertansiyon, kan basıncı, 24 saatlik ambulatuar kan basıncı ölçümü

Evaluation of atherogenic index of plasma levels at hypertensive patients

Aim: Hypertension is a major risk factor for cardiovascular system. Recent studies showed that atherogenic index of plasma (AIP) has a strong association with cardiovascular morbidity, all-cause mortality, atherosclerosis and severity of coronary artery disease. It also has a relationship with endothelial damage in hypertensive patients. With this study we aim to investigate the association between AIP and hypertension.Methods: A total of 213 patients were enrolled for the study. Patients with previous hypertension, nephrotic syndrome, diabetes mellitus, hypotiroidism diagnosis, patients under statin treatment and patients under 18 years of age were excluded. Diagnosis of hypertension and blood pressure (BP) results were obtained with 24-hour ambulatory blood pressure monitoring (ABPM). AIP was defined as the logarithmic transformation of the triglyceride to high-density lipoprotein-cholesterol ratio.Results: Mean age of the population was 49.2 ± 14.6 years and 41.8% (n=89) was male. According to 24-hour ABPM results, AIP was positively correlated with day-time systolic blood pressure (SBP) (r=0.244, p<0.001), day-time diastolic blood pressure (DBP) (r=0.276, p<0.001), night-time SBP (r=0.259, p<0.001), night-time DBP (r=0.299, p<0.001), average SBP (r=0.213, p=0.002) and average DBP (r=0.296, p<0.001). AIP was also increased in hypertensive patients compared to normotensive subjects (p=0.001). Conclusion: Results of our study showed that AIP was positively correlated with blood pressure and statistically higher in patients with hypertension.

Keywords:

Atherogenic index of plasma, hypertension, blood pressure, ambulatory blood pressure monitoring,

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