MEME KANSERİNDE ETKİLİ TIBBİ BİTKİLER VE SEKONDER METABOLİTLERİ

Amaç: Bu derlemede kanıta dayalı bir yaklaşımla meme kanseri tedavisinde destekleyici olabilecek bazı tıbbi bitkilere yer verilmesi amaçlanmıştır.Gereç ve Yöntem: Meme kanseri tedavisinde araştırmalara konu olan tıbbi bitkilerin kapsamlı olarak literatürünün derlenmesi amacıyla sağlık bilimleri alanındaki veritabanlarından yararlanılmıştır. Medline veritabanı ve Scopus ile Web of Science gibi temel atıf indekslerinde daha önce yayınlanmış makaleler için elektronik arama yapılmıştır.Sonuç ve Tartışma: Meme kanserinde kullanılan ilaçların belli bir kısmı bitkilerden elde edilmektedir. Bazı bitkiler detoks mekanizması ile vücudu maligniteden koruyabilir. Biyolojik yanıtı modifiye eden tıbbi bitkiler kanser gelişimini de hormon ve enzim aktivitelerini modifiye ederek engelleyebilirler. Bazı bitkiler de kemoterapi ve radyoterapinin yan etkilerini azaltarak tedaviye destek olabilirler. Bu derlemede meme kanserinde potansiyel etkileri olabilecek 14 tıbbi bitkinin yanı sıra meyve ve sebze olarak tüketilen bazı kaynaklara da yer verimiştir. Türkiye florası çok zengin floraya ve endemik tıbbi bitkilere sahip olmasına rağmen, kanser araştırmaları ve bunlar arasında meme kanseri üzerine yeterli sayıda klinik çalışmanın bulunmayışı floramızın tıbbi araştırmalarda yeterince değerlendirilmediğini göstermektedir.

MEDICINAL PLANTS AND THEIR SECONDARY METABOLITES EFFECTIVE AGAINST BREAST CANCER

Objective: This study aims at reviewing an evidence-based approach to medicinal plants for the supportive treatment of breast cancer.

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