İleri Evre Küçük Hücreli Dışı Akciğer Kanserinde Palyatif Amaçlı Tek Doz 10 Gy Tedavi Şemasının Etkinliği

Amaç: Biz bu çalışmamızda, ileri evre küçük hücreli dışı akciğer kanserli 17 hastada tek doz 10 Gy tedavisinin palyatif etkinliğini araştırmayı amaçladık. Materyal Metod:Daha önce tedavi görmemiş, genel durumu kötü, ileri evre küçük hücreli dışı 15 hastaya kobalt teleterapi cihazı ile tek fraksiyonda 10 Gy palyatif RT uygulanmıştır. Sonuçlar: Tedavi sonrası öksürük yakınması olan 15 hastanın 8’inde komplet (%53), 3’ünde parsiyel (%20); hemoptizisi olan 8 hastanın tümünde komplet (%100) cevap alındı. Göğüs ağrısı olan 11 hastanın 3’ünde parsiyel (%27) parsiyel cevap alınırken 8 hasta cevapsızdı (%72). Nefes darlığı olan 9 hastanın 5’inde parsiyel (%55) cevap gözlenirken 4 hasta tedaviye cevap vermedi (%45). İleri evre, performansı kötü küçük hücreli dışı akciğer kanserli hastalarda özellikle hemoptizi palyasyonu için tek doz 10 Gy radyoterapi uygulanması rasyonel olabili

Anahtar Kelimeler:

Küçük hücreli dışı, akciğer kanseri, palyasyon

The Effectivenes of Single Fraction 10 Gy Treatment Planning in Patients with Advanced Non-Small Cell Lung Cancer

Purpose: In our study we evaluated the effectivenes of single fraction of 10 Gy radiotherapy on non-small cell lung cancer patients who had symptoms such as cough, pain, hemoptysis and dyspnea. Material and Method: Previously untreated fifteen patients who had advanced non-small cell lung cancer and poor prognostic criterions were irradiated by cobalt 60 with 10 Gy doses in single fraction Results: We observed complete response in 8 patients (%53) and partial response in 3 patients (%20) of total number of 15 having cough symptom. We also had complete response in all the patients with hemoptysis, 8 patients out of 8 (%100). Of 11 patients with chest pain we had 3 were partially responsive (% 55) and 4 non responsive (%45) Delivering single dose radiotherapy can be rational for palliation symptoms especially hemoptysis in advanced non-small cell lung cancer patients who have poor performance status

Keywords:

Non-small cell, lung cancer, palliation,

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Chay TK: Role of radiotherapy in advanced carcinoma of the lung. Proceedins 7th Asia-Pasific Congres on Diseases of the Chinese, Nandi PL , Lam WK (Eds) Hong Kong, Southeast Printing Co 1981, pp. 300-304
Perez CA , Stanley K , Grandy G. et al: Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung: Report by the Radiation Therapy Oncology Group. Cancer 1989; 1091-1099
Carroll M , Morgan SA, Yarnold. et all. Prospective evaluation of a watch policy in patients with inoperabl non–small-cell lung cancer. Eur J. Cancer Clin. Oncol, 22, 1353-1356
Fowler JF. : Non-standard fractionation in radiotherapy. Int. J. Radiat. Oncol. Biol Phys. 1984; 10(5) : 755-759
Moore J: Recent advances in radiobiology. In Modern Trends in Radiotherapy, vol.2, Deeley TJ. (Ed.).London, Betherworths. 1972, pp 21-25
Overgoard M: The clinical implications of non-standard fractionation (Letter). Int J. Radiat. Oncol. Biol. Phys. 1985; 11(6): 1225-1227
Peschel RE, Fisher JJ. : Optimization of the time–dose relationship, Sem. Oncol. 1981; 8 (1): 38-48
Withers HR : Biologic basis for altered fractionation scheme. Cancer 1985; 55 (Suppl,9):2086-2095
Peter Teo TH, Tai Domon Cho et al: A randomized study on palliative radiation therapy for inoperable non small cell carcinoma of lung . Int J Radiation Oncology Biol. Phys: 1987; 14: 867-870
Lung Cancer Working Party: In operable non small cell lung cancer: A Medical Research Council randomize trial of palliative radiotherapy with two fraction or ten fraction.
Lung Cancer Working Party, MRC randomize trial of palliative radiotherapy with two fraction or single fraction in patient with inoperable non small cell lung cancer and poor performance status. Br J. Cancer 1992; 65: 934-941