Yıldız GÜNEY, Ayşe BİLGİHAN, Ulukavak ÇİFTÇİ TANSU, Filiz ÇİMEN, Özgür COŞKUN

Akciğer Tüberkulozu ve AkciğerKanserli Hastalarda Serum MalondialdehidSeviyesi ve Süperoksid Dismutaz Aktivitesi

Giriş: Artan orandaki epidemiyolojik ve deneysel çalışmalar serbest radikal aktivitesi ile malignensi arasında yakın ilişki olduğunu göstermiştir. Kanser ve tüberkuloz (tb) gibi dejeneratif hastalıklarda serbest radikal oluşumu ile hücresel savunma mekanizması arasındaki dengesizlik tariflenmiştir. Yöntem: Bu çalışmada akciğer kanserli (Ac Ca) ve tb’lu hastaların serumlarında lipid peroksid seviyesi ve antioksidan bir enzim olan süperoksit dismutaz aktivitesi incelenmiştir. Kırkiki hasta ve ondört sağlıklı gönüllü bu çalışmaya dahil edilmiştir. Malondialdehid (MDA) ve superoksid dismutaz (SOD) aktivitesi serumlarında tespit edildi. Sonuçlar: Serum MDA seviyeleri tüm hasta grubunda (Ac Ca ve tb) kontrol grubuna gore daha yüksek bulunmuştur. MDA düzeylerinde grup I ile grup II arasında belirgin fark göstermemektedir (p>0,05). Ac Ca’li hastaların serumlarında incelenen SOD aktivitesi diğer iki gruba göre belirgin olarak düşüktür. Grup I’deki SOD aktivitesi grup II ile karşılaştırıldığında anlamlı azalma tespit edilmiştir (p<0,001). Bu çalışmada, LP seviyesi hem tb’li hem de Ac Ca’li hastalarda yüksek olmasına karşın, SOD aktivitesi Ac Ca’li hastalarda tb’lu hastalara göre belirgin yüksektir

Anahtar Kelimeler:

Akciğer kanserleri, tuberkuloz, lipid peroksidasyon, superoksid dismutaz

SERUM MALONDIALDEHYDE LEVELS AND SUPEROXIDE DISMUTASE ACTIVITIES IN PULMONARY TUBERCULOSIS AND

Objectives: An increasing amount of epidemiological and experimental evidence has been carried out on the relationship between free radical activity and malignancy. The imbalance between free radical production and cellular defense mechanisms has been described in cancers and degenerative diseases like tuberculosis (tb). Methodology: The present investigation has been undertaken to study the levels of lipid peroxide (LP) and antioxidant enzyme superoxide dismutase (SOD) activities in sera of lung cancers (Lc) and tb. Forty-two patients and fourteen healthy cases were enrolled into the study. Group I had seventeen subjects with Lc, group II had twenty-five patients with tb and group III had fourteen healthy cases. The malondialdehide (MDA) and superoxide dismutase (SOD) activities in sera were quantified. Results: Serum MDA levels in the whole group of patients (Lc and tb) were much higher than in healthy controls. The levels of MDA did not change significantly in the group I vs. group II (p>0,05). The SOD activity in sera from patients with Lc was markedly lower than the other two groups. Activities of SOD in group I significantly decreased as compared to the group II (p<0,001). In the present study although LP levels increased in both tb and Lc patients, the activities of SOD in Lc cases were significantly higher than tb patients.

Keywords:

lung cancers, tuberculosis, lipid peroxidation, superoxide dismutase,

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