The Value of SCUBE-1 on Ischemia-Reperfusion ID Model in Diabetic Patients During Knee Replacement Surgery

Objective: Diabetes Mellitus (DM) is a common disease with high mortality and morbidity worldwide. We aimed to assess the oxidative stress levels in patients with and without DM who underwent knee replacement surgery using a pneumatic tourniquet and investigate whether signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) levels are correlated with other ischemia- reperfusion (IR) markers such as malondialdehyde (MDA), and total antioxidant status (TAS). Method: Patients were assigned into either the diabetic (Group D; n=15) or non-diabetic groups (Group C; n=15). MDA, TAS, and SCUBE-1 were assessed at three time points before spinal anesthesia (T1), 5 minutes before (T2) and 2 hours after deflation of the tourniquet (T3). Results: Demographic variables of the groups were similar. There were no statistically significant differences in SCUBE-1, MDA and TAS levels of both groups at all time points. SCUBE-1 levels were higher at T2 and returned to almost normal levels at T3. Conclusion: SCUBE-1, MDA and TAS levels increased following tourniquet application and decreased during the reperfusion period. The magnitude of increase, however, didn’t differ between patients with or without DM. Our results suggest that SCUBE-1 may be used as a marker of tourniquet-related ischemia-reperfusion model.

Diz Protezi Cerrahisi Sırasında Diyabetik Hastalarda İskemi-Reperfüzyon Modelindeki SCUBE-1’in Değeri

Amaç: Diabetes Mellitus (DM), tüm dünyada yüksek mortalite ve morbiditesi olan yaygın bir hastalıktır. Pnömotik turnike kullanılarak diz protezi ameliyatı yapılan ve DM’i olan ve olmayan hastalar arasındaki oksidatif stres seviyesini belirlemek ve signal peptide-CUB-EGF domaincontaining protein 1 (SCUBE-1) seviyelerinin malondialdehit (MDA) ve total antioksidan durumu (TAS) gibi iskemi reperfüzyon (IR) belirteçleriyle korele olup olmadığını araştırmayı amaçladık. Yöntem: Hastalar diyabetik (grup D; n = 15) veya diyabetik olmayan (grup C; n=15) olarak 2 gruba ayrıldı. MDA, TAS ve SCUBE-1 üç dönemde değerlendirildi: spinal anestezi öncesi (T1), turnike indirilmeden 5 dk. önce (T2) ve turnike indirildikten 2 saat sonra (T3). Bulgular: Grupların demografik özellikleri benzerdi. Her 2 grupta da SCUBE-1, MDA ve TAS düzeyleri bakımından tüm zaman dilimlerinde istatistiksel olarak anlamlı fark yoktu. SCUBE-1 seviyeleri T2’de yükseldi ve T3’te neredeyse normal seviyelere döndü. Sonuç: SCUBE-1, MDA ve TAS seviyeleri turnike uygulamasının ardından arttı ve reperfüzyon döneminde azaldı. Bununla birlikte, artışın derecesi, DM olan veya olmayan hastalar arasında farklılık göstermedi. Sonuçlarımız SCUBE-1’in turnike ile ilişkili iskemi-reperfüzyon modelinin bir belirteci olarak kullanılabileceğini göstermektedir.

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Anestezi Dergisi-Cover
  • ISSN: 1300-0578
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1993
  • Yayıncı: Betül Kartal
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