Amaç: Bu çalışmada sabit doz propofol ile üç farklı doz ketamin infüzyonunun hemodinami, derlenme, postoperatif ağrı ve komplikasyonlar üzerine etkisi ve uygun ketamin dozunun belirlenmesi amaçlandı. Yöntem: Hastane Etik Kurul onayı ve hastaların yazılı izinleri alındıktan sonra genel anestezi altında elektif inguinal herni operasyonu geçirecek 60 hasta rasgele 20 olguluk üç gruba ayrıldı. indüksiyonda 1 mg kg-1 ketamin, 2.5 mg kg-1 propofol intravenöz uygulanmasından sonra ketamin ve propofol infüzyonuna başlandı. Bütün hastalara ilk 10 dk 10 mg kg-1 sa-1 , ikinci 10 dk 8 mg kg-1 sa-1 ve operasyon bitimine kadar 6 mg kg-1 sa-1 propofol infüzyonu yanında Grup I, Grup II ve Grup III de sırasıyla 0.125 mg kg-1 sa-1 , 0.25 mg kg-1 sa-1 ve 0,5 mg kg-1 sa-1 ketamin infüzyonu uygulanıldı. Hastaların demografik ve hemodinamik verileri, derlenme süreleri, postoperatif ilk 24 saatteki VAS değerleri, ilk analjezik zamanı, total analjezik ve propofol miktarı ile gelişen komplikasyonlar kaydedildi. Bulgular: Gruplar arası karşılaştırmalarda peroperatif hemodinamik veriler benzer bulunurken, Grup III hastalarda postoperatif sedasyon daha uzun, ilk analjezik gereksinimi daha geç bulundu (p

Objective: In this study, we aimed to evaluate the effects of three different ketamine-propofol dosing regimes on hemodynamia, patient recovery, postoperative analgesia and complications, as well as to find the most appropriate dose of ketamine. Method: After Hospital Ethical Committee approval and written informed consent, 60 patients, ASA physical status I and II, undergoing general anesthesia for elective inguinal hernia repairing operation were allocated randomly into three equal gro- ups. After all patients received 1 mg kg-1 ketamine and 2.5 mg kg-1 propofol iv at the induction of anesthesia ketamine / propofol infu- sion was started. 0.125 mg kg-1 h-1 , 0,25 mg kg-1 h-1 and 0,5 mg kg-1 h-1 ketamine infusion was started in Group I, II and III pati- ents, respectively. In all patients&#8217; propofol infusion 10 mg kg-1 h-1 for the first 10 min, 8 mg kg-1 h-1 for the second 10 min and 6 mg kg-1 h-1 till the end of the operation was applied. Hemodynamic data, recovery times, postoperative VAS scores in the first 24 ho- urs, the first analgesic requirement time, total analgesic and propofol dose and observed complications were recorded. Results: While perioperative hemodynamic data were found similar between the groups, postoperative sedation duration and first analgesic requirement time was found significantly longer in Group III (p<0,05). Total analgesic consumption was significantly less in Group III (p<0,05). While no patients in Group I have diplopia or dysphoria, 1 and 4 patients in Group II and 4 and 6 patients in Group III showed diplopia and dysphoria, respectively. No psychomimetic side effects were recorded. Conclusion: 0,5 mg kg-1 h-1 ketamine infusion combined with propofol infusion could be a good alternative for TIVA with its cardiovascular stability, postoperative sedation, late and lower analgesia requirement and no psychomimetic side effects.