Petek ÖYEKCİN, Semih KÜÇÜKGÜÇLÜ, Mustafa AKHİSAROĞLU, Atalay ARKAN

Gebe tavşanlarda bupivakainin oluşturduğu epileptiform EEG aktivitesi üzerine efedrinin etkisi

Bu çalışmanın amacı gebe tavşanlara toksik dozlarda uygulanan bupivakaine eklenen efedrinin konvülziyon eşiği üzerine etkisini araştırmaktır. Yöntem: Araştırmaya 21 adet gebe tavşan alındı. Araştırmanın birinci günü, deneklerin her iki hemisferine EEG monitörizasyonu için soket yerleştirildi. İkinci gün uyanık ve spontan soluyan denekler randomize 3 gruba ayrıldı ve Grup Ve (n-7) 1.5 mg kg'dk' bupivakain; Grup 2'ye (n=7) 1.5 mg kg'dk1 bupivakain ile 50 fig kg'dk'1 efedrin; Grup 3'e (n=7) 1.5 mg kg'dk'1 bupivakain ile 100 ng kg1 dk1 efedrin intravenöz infüzyonlar şeklinde uygulandı. Bupivakain verilmesinden EEG'ye ait ilk diken-dalga kompleksinin oluşmasına kadar geçen süre ve verilen toplam ilaç dozları hesaplandı. Bazal, EEG'deki diken kompleksi oluşma sırasında ve 5 dakika sonrasındaki glukoz, Na+ ve K+ değerleri ölçüldü. Bulgular: Diken kompleksi gelişinceye kadar geçen ortalama süre Grup Vde 31.30 sn, Grup 2'de 24.53 sn ve Grup 3'de 10.37 sn olup tüm gruplarda anlamlı farklı bulundu (p

Anahtar Kelimeler:

Tavşanlar, Modeller, hayvan, Bupivakain, Efedrin, Nöbetler, Gebelik, Elektroensefalografi

The effect of ephedrine sulfate on intravenous bupivacaine-induced epileptiform electroencephalogram activity in pregnant rabbits

Objective: To examine the role of ephedrine on the effects of convulsion thresholds caused by toxic doses ofbupivacaine. Methods: 21 pregnant rabbits were included in this study. On the first day of the study, sockets were placed on both hemispheres of all rabbits for monitoring the EEG signals. On the second day, the awake spontaneously breathing animals were divided into three groups randomly. Group 1 (n=7) was given 1.5 mg kg'min1 of bupivacaine; Group 2 (n=7) was given 1.5 mg kg'1 min'1 of bupivacaine with 50 ng kg^min'1 of ephedrine sulfate; and Group 3 (n=7) was given 1.5 mg kg min'1 of bupivacaine with 100 jig kg'1 min'1 of ephedrine sulfate as intravenous infusions. The time to appearance of spikes, the total drug doses with serum glucose, Na+ and K+ levels were measured at baseline, at the time of first EEG spike appearance and at 5 minutes later. Results: The spike times were measured as 31.30, 24.53 and 10.37 sec in Group 1, 2 and 3 respectively and the differences among them were statistically significant (p<0.01). Total bupivacaine doses were 2.28,1.6 and 0.7 mg in the groups respectively and the difference between the groups were significant (p<0.01). There were no differences in total ephedrine doses between the groups. Conclusion: The result of our study showed that ephedrine decreases the threshold of convulsion in pregnant rabbits receiving toxic doses of bupivacaine.

Keywords:

Rabbits, Models, Animal, Bupivacaine, Ephedrine, Seizures, Pregnancy, Electroencephalography,

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