Etkin Hasta Kan Yönetimi

Son yıllarda kan ve kan bileşenleri transfüzyonunun komplikasyonları, mortalite ve morbiditeye etkileri ve maliyet üzerindeki yükleri hakkındaki farkındalık artmış ve bu, transfüzyon uygulama- sına yeni bir yaklaşım gereksinimi oluşturmuştur. “Hasta Kan Yönetimi (HKY)” olarak tanımlanan bu yeni yaklaşım; doğru zamanda, doğru hastaya, doğru ürünle transfüzyon yapılmasını hedefler. Birçok diğer yerleşmiş ve neredeyse kültür haline gelmiş tıbbi uygulamada olduğu gibi, var olan transfüzyon alışkanlıklarının da bu yeni yaklaşımla değiştirilebilmesi oldukça zor olmaktadır. HKY’nin amaç, içeriği ve sonuçlarıyla ilgili artan sayıda yayına rağmen, etkin bir biçimde nasıl uygulamaya yerleştirileceği konusundaki deneyim ve çalışmalarla ilgili yayınlar sınırlıdır. Bu makalede, bu yayınlar ve HKY projesini başarılı ve yaygın olarak kullanmakta olan Avusturalya ve ABD’nin deneyim ve yöntemleri derlenmiştir.

Effective Patient Blood Management

Awareness about complications of transfusions of blood and blood products, their effects on mortality and morbidity and cost burden has increased in recent years which created the need for a new approach to transfusion practice. This new approach, defined as “Patient Blood Management (PBM)” aims to transfuse the right blood product to the right patient at the right time. Alteration of transfusion habits according to this new approach is quite difficult as seen in changing many established, traditional medical practices. Although there have been an increas- ing number of publications about the aim, context and results of PBM, there is limited studies and experience about the efficient implementation of this practice. In this article, the reports and clinical experiences of countries like USA and Australia that widely and successfully use this PBM project are reviewed.

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  • Giangrande PLF. Thehistory of blood transfusion. Br J Haem. 2000;110:758-67. https://doi.org/10.1046/j.1365-2141.2000.02139.x
  • Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. First of two parts-- bloodtransfusion. N Engl J Med. 1999;340:438-47. https://doi.org/10.1056/NEJM199902113400606
  • Boucher BA, Hannon TJ. Blood management: a primer for clinicians. Pharmacotherapy. 2007;27:1394-411. https://doi.org/10.1592/phco.27.10.1394
  • Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, andsepsis in general surgery patients. J Am Coll Surg. 2009;208:931-7. https://doi.org/10.1016/j.jamcollsurg.2008.11.019
  • Engoren M, Schwann TA, Habib RH, Neill SN, Vance JL, Likosky DS. The independent effects of anemia and transfusion on mortality after coronary artery bypass. Ann Thorac Surg. 2014;97:514-20. https://doi.org/10.1016/j.athoracsur.2013.09.019
  • Perisanidis C, Dettke M, Papadogeorgakis N, Schoppmann A, Mittlböck M, Kyzas PA. Transfusion of allogenic leukocyte-depleted packed red blood cells is associated with postoperative morbidity in patients undergoing oral and oropharyngeal cancer surgery. Oral Oncol. 2012;48:372-8. https://doi.org/10.1016/j.oraloncology.2011.11.020
  • Farmer SL, Trentino K, Hofmann A, et al. A Programmatic Approach to Patient Blood Management - Reducing Transfusions and Improving Patient outcomes. The Open Anesthesiol J. 2015;9:6-16. https://doi.org/10.2174/1874321801509010006
  • Spahn DR. Anemia and patient blood management in hip and knee surgery: a systematic review of the litera- ture. Anesthesiology 2010;113:482-95. https://doi.org/10.1097/ALN.0b013e3181e08e97
  • Bennett-Guerrero E, Zhao Y, O’Brien SM, et al. Variation in use of blood transfusion in coronary artery bypass graft surgery. JAMA 2010;304:1568-75. https://doi.org/10.1001/jama.2010.1406
  • Acheson AG, Brookes MJ, Spahn DR. Effects of allogenic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a syste- matic review and meta-analysis. Ann Surg.2012;256:235-44. https://doi.org/10.1097/SLA.0b013e31825b35d5
  • Hutton B, Fergusson D, Tinmouth A, McIntyre L, Kmetic A, Hébert PC. Transfusion rates vary significantly amongst Canadian medical centres. Can J Anaesth. 2005;52:581-90. https://doi.org/10.1007/BF03015766
  • Yang X, Alexander KP, Chen AY, et al. The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative. J Am Coll Cardiol. 2005;46:1490-5. https://doi.org/10.1016/j.jacc.2005.06.072
  • Shander A, Fink A, Javidroozi M, et al. Appropriateness of allogeneic red blood cell transfusion: the internatio- nal consensus conference on transfusion outcomes. Transfus Med Rev. 2011;25:232-46. https://doi.org/10.1016/j.tmrv.2011.02.001
  • Goodnough LT, Shander A. Blood management. Arch Pathol Lab Med. 2007;131:695-701.
  • WHA 63.12 - Availability, Safety and Quality of Blood Products. WHA resolution; Sixty-third World Health Assembly. Geneva: World Health Organization; 2010.
  • Goel R, Shi PA. Patient Blood Management. In: Shaz BH, Hillyer CD, Gil MR, editors. Transfusion Medicine and Hemostasis (Third Edition). Elsevier, 2019. 371-8. https://doi.org/10.1016/B978-0-12-813726-0.00059-3
  • Goodnough LT, Shander A. Patient blood management. Anesthesiology. 2012;116:1367-76. https://doi.org/10.1097/ALN.0b013e318254d1a3
  • Grimshaw JM, Shirran L, Thomas R, et al. Changing provider behavior: an overview of systematic reviews of interventions. Medical Care. 2001;39:II2-45. https://doi.org/10.1097/00005650-200108002-00002
  • Kinsman L, James E, Ham J. An interdisciplinary, evidence-basedprocess of clinical pathway implemen- tation increases pathway usage. Lippincott’s case management: managing the process of patient care. 2004;9:184-96. https://doi.org/10.1097/00129234-200407000-00006
  • National Blood Authority. Patient Blood Management Guidelines implementation strategy 2013-2017. Available from: https://www.blood.gov.au/system/ files/National-Patient-Blood-Management-Strategy- 2017-2021-Final.pdf.
  • Frank SM, Thakkar RN, Podlasek SJ, et al. Implementing a health system-wide patient blood management program with a clinical community approach. Anesthesiology. 2017;127:754-64. https://doi.org/10.1097/ALN.0000000000001851
  • Sadana D, Pratzer A, Scher LJ, et al. Promoting high- value practice by reducing unnecessary transfusions with a patient blood management program. JAMA Intern Med. 2018;178:116-22. https://doi.org/10.1001/jamainternmed.2017.6369
  • Yazer MH, Waters JH. How do I implement a hospital- based blood management program? Transfusion. 2012;52:1640-5. https://doi.org/10.1111/j.1537-2995.2011.03451.x
  • Podlasek SJ, Thakkar RN, Rotello LC, et al. Implementing a ‘Why give 2 when 1 will do?’ Choosing Wisely cam- paign. Transfusion. 2016;56:2164. https://doi.org/10.1111/trf.13664
  • Oliver JC, Griffin RL, Hannon T, Marques MB. The suc- cess of our patient blood management program depended on an institution-wide change in transfusion practices.Transfusion. 2014;54:2617-24. https://doi.org/10.1111/trf.12536
  • Zuckerberg GS, Scott AV, Wasey JO, et al. Efficacy of education followed by computerized provider order entry with clinician decision support to reduce red blood cell utilization. Transfusion. 2015;55:1628-36. https://doi.org/10.1111/trf.13003
  • Yeh DD, Naraghi L, Larentzakis A, et al. Peer-to-peer physician feedback improves adherence to blood transfusion guidelines in the surgical intensive care unit. J Trauma Acute Care Surg. 2015;79:65-70. https://doi.org/10.1097/TA.0000000000000683
  • Goodnough LT, Shieh L, HadhazyE, ChengN, Khari P, Maggio P. Improved blood utilization using real-time clinical decision support. Transfusion. 2014;54:1358- 65. https://doi.org/10.1111/trf.12445
  • Hicks CW, Liu J, Yang WW, et al. A comprehensive Choosing Wisely quality improvement initiative redu- ces unnecessary transfusions in an Academic Department of Surgery. Am J Surg. 2017;214:571-6. https://doi.org/10.1016/j.amjsurg.2017.06.020
  • Tinmouth A, Macdougall L, Fergusson D, et al. Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians’ transfusion practices. Arch Intern Med. 2005;165:845- 52. https://doi.org/10.1001/archinte.165.8.845
  • Kotter JP, Schlesinger LA. Choosing strategies for chan- ge. Harv Bus Rev. 1979;57:106-14.
  • National Blood Authority Australia. Availablefrom: https://www.blood.gov.au/
  • Leahy MF, Hofmann A, Towler S, et al. Improved outco- mes and reduced costs associated with a health- system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals. Transfusion. 2017;57:1347-58. https://doi.org/10.1111/trf.14006
  • Proceedings from the National Summit on Overuse [Internet]. Oakbrook Terrace (IL): The Joint Commission; 2012 [cited 2016 Jun 17]. Available from: https://www. jointcommission.org/assets/1/6/national_summit_ overuse.pdf
  • Thakkar RN, Lee KH, Ness PM, et al. Relative impact of a patient blood management program on utilization of all three major blood components. Transfusion. 2016;56:2212-20. https://doi.org/10.1111/trf.13718
Anestezi Dergisi-Cover
  • ISSN: 1300-0578
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1993
  • Yayıncı: Betül Kartal
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