Anestezi Çalışanlarında Çalışma Ortamından Uzaklaşmanın Oksidatif Stres Düzeylerine Etkisinin Dinamik Tiyol Disülfit Dengesi ile Değerlendirilmesi

Amaç: Atık gaz maruziyeti ve mesleki stres nedeniyle anestezi çalışanlarında oksidatif stres artmaktadır. Çalışmamızda, anestezi çalışanlarında minimum 1 hafta anestezi pratiğinden uzaklaşılmasının, oksidatif stres üzerine etkilerinin tiyol disülfit dengesiyle incelenmesi amaçlandı. Yöntem: Çalışmaya ameliyat odasında anestezi uygulamalarında aktif çalışan ve en az 1 hafta izne çıkmayı planlayan anesteziyoloji uzmanı, uzmanlık öğrencisi ve anestezi teknisyenleri arasından toplam 29 gönüllü dâhil edildi. Demografik verileri, çalışma süreleri ve görevleri kaydedildi. Gönüllülerden izne ayrılmadan önceki gün ve izinden döndüğü gün kan alınarak dinamik tiyol disülfit dengesi çalışıldı. İzin sonrası nativ ve total tiyol düzeylerinde artma ve disülfidde azalma oksidatif stres düzeyinde azalma olarak değerlendirildi. Veriler t-testi, tek yönlü varyans analizi, eşleştirilmiş t-testi ile değerlendirildi, p

Evaluating the Effect of Being Away From Work Environment on Oxidative Stress Levels with Dynamic Thiol-Disulfide Homeostasis Among Anesthesiology Professionals

Objective: Exposure to anesthetic gases and occupational stress lead to increased levels of oxidative stress in anesthesiology professionals. Our study aims to investigate the effects of being away from anesthetic practice on oxidative stress with thiol-disulfide balance in anesthesiology professionals. Method: The study included a total of 29 volunteers among anesthesiologists, residents and technicians working in anesthesiology practice and planning to take a leave lasting at least for a week. Demographic data, working times and duties of them were recorded. Blood samples were taken from the participants on the day before they went on leave and on the day they returned, to study dynamic thiol-disulfide homeostasis. Increased native and total thiol levels and decreased disulfide levels after returning were evaluated as a decrease in oxidative stress. The data were assessed with a t-test, a one-way analysis of variance, a paired t-test; and p

Kaynakça

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