Varikosel patofizyolojisi 2019

Erkek infertilitesinin en sık düzeltilebilir patolojisi olarak saptanan varikosel, normal popülasyonda yaklaşık olarak %13–15 oranlarında belirlenmektedir. Genel popülasyonda bu kadar yüksek oranlarda saptanması ve hastaların %11,7’sinde de semen parametrelerinin normal değerlerde tespit edilmesi, varikosel ve infertilite arasındaki patofizyolojik süreçlerin değerlendirilmesinde yeni araştırma konularını gündeme getirmiştir. Konvansiyonel olarak varikoselin erkek üreme sistemine olası patofizyolojik etkisi, beş ayrı mekanizma ile değerlendirilmektedir. Bu mekanizmalar; hipertermi, hipoksi, toksik sürrenal metabolitlerin reflüsü, hipogonadizm ve kadmium birikmesi olarak bildirilmektedir.

Pathophysiology of varicocele 2019

Varicocele, which is the most frequently treatable pathology of male infertility, is detected in approximately 13–15% of the normal population. Determination of such high rates in the general population and the detection of semen parameters in normal values in 11.7% of patients has led to new research topics to evaluation of the pathophysiological processes between varicocele and infertility. Conventionally, the possible pathophysiological effect of varicocele on male reproductive system is evaluated by five different mechanisms. These mechanisms are reported as hyperthermia, hypoxia, reflux of toxic cyclical metabolites, hypogonadism, and cadmium accumulation.

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