Correlation between gross morphology of the human placenta and birth weight in normotensive and pre-eclamptic pregnancies in Northwest Ethiopia
Objectives: The objective of this study was to investigate correlation of gross morphology of human placenta with birthweight in normotensive and pre-eclamptic pregnancies obtained from Bahir Dar, Northwest Ethiopia.Methods: Institutional based comparative cross-sectional study was carried out on 200 term placentas (37 to 42 weeks of gestation)between October and January 2015. 150 placentas from normotensive and 50 from pre-eclamptic pregnancies were collectedand examined for weight, diameter, thickness and number of cotyledon. Birth weight and placental-fetal weight ratio alsomeasured.Results: The mean birth weight in pre-eclamptic pregnancies (2.6 kg) was significantly (p=0.0001) reduced as compared to birthweight (3.1 kg) in normotensive pregnancies. However, placental-fetal weight ratio had no significant (p=0.658) differencebetween normotensive (6.34:1) and pre-eclamptic (6.41:1) groups. Birth weight was correlated with placental weight (r=0.572),diameter (r=0.583), thickness (r=0.192) and number of cotyledons (r=0.647) in the pre-eclamptic group. Birth weight was alsocorrelated with placental weight (r=0.572), diameter (r=0.583), and number of cotyledons (r=0.647) in the normotensive group.However, no correlation was found between placental thickness (r=0.192) and birth weight in the normotensive group.Conclusion: Birth weight was significantly reduced in pre-eclamptic pregnancies as compared to normotensive pregnancies.Morphology of placenta such as weight, diameter and number of cotyledons were correlated with birth weight in bothgroups, but placental thickness was only correlated with birth weight in pre-eclampsia, but not in normotensive group.Placental-fetal weight ratio had not significant difference between the groups. Examination of placental morphology prenatallyusing ultrasound and observation immediately after delivery is important for better management of this and subsequentpregnancies.
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- 1. Mardi K, Sharma J. Histopathological evaluation of placentas in
IUGR pregnancies. Indian J Pathol Microbiol 2003;2:1–4.
- 2. Jain A, Sharma D, Sharma V, Baweja S, Jain R. Study of placental
weight in normal and pre-eclamptic pregnancies and its correlation
with birth weight. International Journal of Medical Research and
Review 2016;4:2–8.
- 3. Goswami P, Memon S, Rathore MI. Foeto-placental weight relationship
in normal pregnancy and pregnancies complicated by pregnancy
induced hypertension and abruption of placentae.
International Journal of Research in Medical Sciences 2015;3:1081–
4.
- 4. Sirpurkar M, Anjankar VP. Study of correlation between placental
morphology and adverse perinatal outcome in different conditions
affecting pregnancy. International Journal of Reproduction,
Contraception, Obstetrics and Gynecology 2015;4:1165–8.
- 5. Kambale T, Iqbal B, Ramraje S, Swaimul K, Salve S. Placental morphology
and fetal implications in pregnancies complicated by pregnancy-
induced hypertension. Medical Journal of DY Patil University
2016;9:341–7.
- 6. Gupta C, Harode HA, D’souza AS, Sharma A. A morphological and
morphometric study of placenta with its clinical implications.
Tropical Journal of Medical Research 2015;18:85–8.
- 7. Susmita S, Lopamudra N, Shashi SB, Prafulla KC. Morphometric
study of placenta of full term new born & its relation to fetal weight:
a study in Tertiary Care Hospital of Odisha. Journal of Evolution of
Medical and Dental Sciences 2015;4:742–7.
- 8. Londhe PS, Mane AB. Morphometric study of placenta and its correlation
in normotensive and hypertensive pregnancies. International
Journal of Pharma and Bio Sciences 2011;2:429–37.
- 9. Aremu AA, Atanda OO, Adeomi AA. Newborn birth weight and placental
parameters in normal human pregnancies. Journal of
Pharmaceutical and Biomedical Sciences 2013;30:23–7.
- 10. Sankar KD, Bhanu PS, Ramalingam K, Kiran S, Ramakrishna BA.
Histomorphological and morphometrical changes of placental terminal
villi of normotensive and preeclamptic mothers. Anat Cell Biol
2013;46:285–90.
- 11. Gundalli SM, Kolekar R, Sunita VN, Nandurkar V. Placenta in
eclampsia and pre-eclampsia. IOSR Journal of Dental and Medical
Sciences 2015;14:46–51.
- 12. Shevade S, Arole V, Vaishaly B, Paranjape V. Placental morphology
and fetal outcome in preeclampsia and normotensive pregnancies.
IOSR Journal of Dental and Medical Sciences 2015;14:11–5.
- 13. Kaur P, Kaushal S, Singh K, Sharma A. Placental weight, birth
weight and fetal outcme in preeclampsia and normotensive pregnancies.
International Journal of Plant, Animal and Environmental
Sciences 2013;3:30–34.
- 14. Singh S, Gugapriya TS. A cross sectional morphometric study of
hypertensive with normal placentae and its correkation with fetal
outcome. International Journal of Anatomy and Research
2014;2:437–42.
- 15. Raghavendra AY, Vinay KV, Pai V. A study of placental weight and
fetal outcome in different grades of pregnancy induced hypertension.
International Journal of Anatomy and Research 2014;2:625–9.
- 16. Pathak S, Sebire NJ, Hook L, Hackett G, Murdoch E. Relationship
between placental morphology and histological findings in an unselected
population near term. Virchows Arch 2011;459:11–20.
- 17. Ullah E. Unfavorable effects of pre-eclampsia on the morphology of
the placenta. Pakistan Journal of Medical and Health Sciences.
2013;7:207–11.
- 18. Pathak S. Morphological and histological placental characteristics in
relation to pregnancy outcome in an unselected population. Doctoral
dissertation, University of East Anglia, Norwchich, Norfolk, UK,
2010.
- 19. Girish BL, Nandagopal KM, Padmini CP, Mahesh SH, Ragunatha
S, Srinath S. A morphometric comparative study of placenta in normal
and preeclampsia pregnancies delivering at 36 to 38 weeks of
gestation and its impact on birth weight. Journal of Evolution of
Medical and Dental Sciences 2015;4:14444–50.