The effects of methylphenidate on weight, height, and body mass index in Turkish children and adolescents with ADHD

Objective: The pathophysiological mechanisms underlying the effects of psychostimulants (methylphenidate)treatment on growth still remain controversial. We examined the long term effects of methylphenidate on height, weight and body mass index in Turkish children and adolescents with attention deficit hyperactivity disorder (ADHD).Methods: Participants (6-18 years, 330 boys, 103 girls) diagnosed with ADHD who received treatment with methylphenidate for at least 1 year at the Department of Child and Adolescent Psychiatry at Dokuz Eylül University Medical School were included in a retrospective study. Weight, height, and BMI z scores were converted to age- and gendercorrected z scores using norms from the Turkish population at baseline and last follow-up. Results: Height and weight standard deviation score (SDS) were reduced by treatment (baseline height-SDS [SDS]: 0.74±1.43, followup height-SDS [SDS]: -0.67±4.35, t-test p

DEHB tanılı Türk çocuk ve ergenlerde metilfenidatın ağırlık, boy ve beden kitle indeksi üzerine etkisi

Amaç: Psikostimülan (metilfenidat) tedavisinin büyüme üzerindeki etkilerinin altında yatan patofizyolojik mekanizmalar hala tartışmalıdır. Dikkat eksikliği hiperaktivite bozukluğu (DEHB) olan Türk çocuklarında ve ergenlerinde metilfenidatın boy, kilo ve beden kitle indeksi (BKİ) üzerindeki uzun dönem etkilerinin araştırılması planlanmıştır. Yöntem: Dokuz Eylül Üniversitesi Tıp Fakültesi Çocuk ve Ergen Psikiyatrisi Anabilim Dalı'nda en az 1 yıl boyunca metilfenidat tedavi edilmiş DEHB’li katılımcılar (6-18 yaş, 330 erkek, 103 kız) geriye dönük taranarak çalışmaya alınmıştır. Tedaviye başlamadan önce ve izleme sürecinde ağırlık, boy ve BKİ değerleri, Türk toplum normları kullanarak yaşa ve cinsiyete göre düzeltilmiş z puanlarına dönüştürülmüştür. Bulgular: Boy ve ağırlık z standart sapma puanlarının (SDS) tedavi ile azaldığı saptandı (başlangıç boy-SDS [SDS]: 0.74±1.43, izlem boy-SDS [SDS]:-0.67±4.35, t-testi p

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