İBRAHİM TOLGA BİNBAY, Deniz ARIK BİNBAY, Halis ULAŞ, BERNA BİNNUR AKDEDE, KÖKSAL ALPTEKİN

Şizofrenide anne-baba akraba evliliğinin klinik özelliklere etkisi

Amaç: Şizofreni hastalarının anne-babalarında akraba evliliğinin klinik özellikler üzerine etkisini incelemektir. Yöntem: Araştırmanın örneklemini 2009-2011 yılları arasında Sinop Atatürk Devlet Hastanesi'ne başvuran DSMIV tanı sistemine göre şizofreni tanısı konan hastalar oluşturmuştur. Hastaların yaş, cinsiyet, eğitim durumu, sosyoekonomik konum, çalışma durumu, ailede psikiyatrik hastalık öyküsü, hastalık başlangıç yaşı ve hastane yatış sayısı bilgileri ile anne-baba akraba evliliği durumları ve derecesi (birinci derece kuzen evliliği) hasta dosyalarından ve kayıtlardan geriye dönük olarak elde edilmiştir. Bulgular: Yüz seksen iki hasta (%51.1 kadın ve yaş ortalaması 38.8) alınmıştır. Anne-babalarda akraba evliliği ve birinci derece kuzen evliliği oranı sırasıyla %19.9 ve %13.2 olarak saptanmıştır. Hastalık başlangıç yaşı ortalaması anne-baba akraba evliliği olan hastalarda olmayanlara göre daha erken (sırasıyla 22.1 ve 25.5; t(180)=2.1; p

Impact of parental consanguinity on clinical features in schizophrenia

Objective: The purpose of this study was to evaluate the impact of parental consanguinity on the clinical features in schizophrenia. Methods: The sample of the study was based on DSM-IV schizophrenia patients admitted to Atatürk State Hospital of Sinop between 2009 and 2001. Sociodemographic (age, gender, marital status, completed years of education, employment status) and clinical features (family history of psychiatric disorders, age of onset, number of hospitalization), and parental consanguinity were retrieved retrospectively from case registries. Results: A total of 182 patients (51.1% female and mean age 38.8) were included. Frequency of any parental consanguinity and first degree cousin marriages were 19.9% and 13.2% respectively. Mean age of onset of schizophrenia was significantly lower among patients with parental consanguinity than patients with no parental consanguinity (22.1 and 25.5 respectively; t180=2.1; p<0.05). Parental consanguinity was significantly associated with higher number of hospitalization (adjusted odds ratio [OR]=2.8; 95% confidence interval [CI]=1.1-7.1; p<0.02). The association between parental consanguinity and number of hospitalization was slightly stronger in

PDF

___

1. Teebi AS, El-Shanti HI. Consanguinity: implications for practice, research, and policy. Lancet 2006; 367:970-971.
2. Uskun E. Akraba evlilikleri. Sürekli Tıp Eğitimi Dergisi 2001; 10:54-56.
3. Bittles A. A community genetics perspective on consanguineous marriage. Cummunirt Genet 2008; 11:324-330.
4. Akbayram S, Sari N, Akgün C, Doğan M, Tuncer O, Caksen H, et al. The frequency of consanguineous marriage in eastern Turkey. Genet Couns 2008; 20:207-214.
5. Çiçeklioğlu M, Ergin I, Demirelöz M, Ceber E, Nazlı A. Sociodemographic aspects of consanguineous marriage in an urban slum of a metropolitan area in İzmir, Turkey. Annals Hum Biol 2013; 40:139-145.
6. Koc I. Prevalence and sociodemographic correlates of consanguineous marriages in Turkey. J Biosoc Sci 2008; 40:137-148.
7. Alper OM, Erengin H, Manguoglu AE, Bilgen T, Çetin Z, Dedeoğlu N, et al. Consanguineous marriages in the province of Antalya, Turkey. Ann Genet 2004; 47:129-138.
8. Tuncbilek E. Clinical outcomes of consanguineous marriages in Turkey. Turk J Pediatr 2001; 43:277-279.
9. Rudan I, Campbell H, Carothers AD, Hastie ND, Wright AF. Contribution of consanguinuity to polygenic and multifactorial diseases. Nat Genet 2006; 38:1224-1225.
10. van Os J, Kenis G, Rutten BP. The environment and schizophrenia. Nature 2010; 468:203-212.
11. Kavanagh DH, Tansey KE, O'Donovan MC, Owen MJ. Schizophrenia genetics: emerging themes for a complex disorder. Mol Psychiatry 2015; 20:72-76.
12. Bassett AS, Scherer SW, Brzustowicz LM. Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease. Am J Psychiatry 2010; 167:899- 914.
13. Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511:421-427.
14. Ahmed AH. Consanguinity and schizophrenia in Sudan. Br J Psychiatry 1979; 134:635-636.
15. Chaleby K, Tuma TA. Cousin marriages and schizophrenia in Saudi Arabia. Br J Psychiatry 1987; 150:547-549.
16. Bener A, Dafeeah EE, Samson N. Does consanguinity increase the risk of schizophrenia? Study based on primary health care centre visits. Ment Health Fam Med 2012; 9:241-248.
17. Bener A, Dafeeah EE, Samson N. The impact of consanguinity on risk of schizophrenia. Psychopathology 2012; 45:399-400.
18. Mansour H, Fathi W, Klei L, Wood J, Chowdari K, Watson A, et al. Consanguinity and increased risk for schizophrenia in Egypt. Schizophr Res 2010; 120:108-112.
19. Dobrusin M, Weitzman D, Levine J, Kramer I, Rietschel M, Maier W, et al. The rate of consanguineous marriages among parents of schizophrenic patients in the Arab Bedouin population in Southern Israel. World J Biol Psychiatry 2009; 10:334-336.
20. Cansu A, Serdaroglu A, Yuksel D, Doğan V, Ozkan S, Hirfanoğlu T, et al. Prevalence of some risk factors in children with epilepsy compared to their controls. Seizure 2007; 16:338-344.
21. Kilic SS, Ozel M, Hafizoglu D, Karaca NE, Aksu G, Kutukculer N. The prevalences [correction] and patient characteristics of primary immunodeficiency diseases in Turkey--two centers study. J Clin Immunol 2013; 33:74-83.
22. Sahin O, Yildirim C, Akgun RC, Haberal B, Yazici AC, Tuncay IC. Consanguineous marriage and increased risk of idiopathic congenital talipes equinovarus: a case-control study in a rural area. J Pediatr Orthop 2013; 33:333-338.
23. Guner SI, Guner S, Peker E, Ceylan MF, Guler A, Turktas U, et al. Are consanguineous marriage and swaddling the risk factors of developmental dysplasia of the hip? J Membr Biol 2013; 246:115-119.
24. Basgul SS, Etiler N, Cakin-Memik N, Coskun A, Agaoglu B. Frequency and correlates of psychiatric disorders in early childhood: a study of population and clinical samples in Turkey. Turk J Pediatr 2011; 53:666-679.
25. Erkin G, Delialioglu SU, Ozel S, Culha C, Sirzai H. Risk factors and clinical profiles in Turkish children with cerebral palsy: analysis of 625 cases. Int J Rehabil Res 2008; 31:89-91.
26. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington D.C.: American Psychiatric Press, 1996.
27. Binbay T, Arık Binbay D, Ulaş H, Alptekin K. Sinop ilinde tanımlı bir alanda şizofreni, şizoafektif bozukluk ve bipolar I bozukluğun başvuru temelli yaygınlığı. Türk Psikiyatr Derg 2016; doi: 10.5080/u13743.
28. Aile ve Sosyal Politikalar Bakanlığı. Türkiye Aile Yapısı Araştırması. Aile ve Toplum Hizmetleri Genel Müdürlüğü, Araştırma ve Sosyal Politika Serisi 04, ikinci basım, Ankara, 2014.
29. TÜİK. İstatistiklerle Gençlik 2011. Ankara: Türkiye İstatistik Kurumu, 2012.
30. Elmacı AM, Ece A, Akın F. Pediatric urolithiasis: metabolic risk factors and follow-up results in a Turkish region with endemic stone disease. Urolithiasis 2014; 42:421-426.
31. Lohmann E, Hanagasi HA, Gürvit H, Kayacı G, Ruberg M, Yazıcı J, et al. The impact of familial structure on Parkinson's disease in Istanbul Medical School, Turkey. Int J Neurosci 2012; 122:102-105.
32. Bittles AH, Black ML. Consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci USA 2010; 107(Suppl.1):1779-1786.
33. Mortensen PB, Pedersen MG, Pedersen CB. Psychiatric family history and schizophrenia risk in Denmark: which mental disorders are relevant? Psychol Med 2010; 40:201-210.
34. Kao YC, Liu YP. Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders. BMC Psychiatry 2010; 10:63.