Depresyonda plazma ksantin oksidaz, glutatyon peroksidaz aktiviteleri ve plazma nitrik oksit seviyesi üzerine egzersizin etkisi

Amaç: Depresyonlu olgularda egzersiz sonrası plazma glutatiyon peroksidaz (GSH-Px) ve ksantin oksidaz (X0) aktiviteleri ile plazma NO seviyesinde olan değişikliklerin incelenmesi amaçlanmıştır. Yöntem: Genel Sağlık Anketi (GSA), Beck Depresyon Ölçeği (BDÖ), Spielberg Durumluk-Sürekli Kaygı Envanteri (SDSKE) ve Hamilton Depresyon Derecelendirme Ölçeğinin (HDDÖ) uygulanmasını takiben bir psikiyatri uzmanı tarafından yapılan psikiyatrik görüşme ile gönüllü sekiz sağlıklı ve sekiz depresyonludan oluşan gruplar belirlendi. Kontrol ve depresyon gruplarında yaş ortalamaları sırasıyla 20.75±1.04 ve 20.25$pm$1.67 yıldı. Her iki gruba haftada üç gün 20-25 dakika devam eden dokuz hafta süren egzersiz program uygulandı. Dokuz haftalık egzersiz programı öncesi ve sonrası açlık kan örnekleri alındı ve plazma ayrıldı. Plazma glutatyon peroksidaz (GSH-Px) ksantin oksidaz (XO) aktiviteleri ve plazma nitrik oksit (NO) düzeyi tespit edildi. Bulgular: Plazma GSH-Px aktivitesi ve N0 seviyesi her iki grupta da egzersiz sonrası değişiklik göstermedi. Kontrol grubu XO aktivitesinde egzersiz sonrası bir azalma tespit edildi. Depresyon grubu XO aktivitesi egzersiz sonrası anlamlı artış gösterdi Depresyon grubu XO aktivitesi egzersiz sonrası kontrole göre anlamlı olarak yüksek bulundu. Depresyon grubunda egzersiz sonrası XO aktivitesi ile GSH-Px aktivitesi arasında pozitif korelasyon vardı. Tartışma: Düzenli egzersizin bir antioksidan gibi işlev görerek depresyonun tedavisinde katkıda bulunduğu düşünülmektedir. (Anadolu Psikiyatri Dergisi 2001; 2(2):99-105)

Effects of exercise on plasma activities of xanthine oxidase and glutathion peroxidase, and on levels of plasma nitric oxide in depression

Objective: The purpose of this study was to assess differences of plasma glutathion peroxidase GSH-Px) and xanthine oxidase (XO) activities and plasma nitric oxide (NO) levels in depressive 'patients after exercise. Method: Eight healthy and eight depressive cases volunteered to complete the General Health Questionnaire (GHQ), the Beck Depression Inventory BDI the Spielberg State-Trait Anxiety Inventory (STAI) and Hamilton Depression Rating Scale (HDRS). The psychiatric „evaluation was done by a psychiatrist. The mean ages of control and depression groups were 20.75+1.04 and 20.25'±1.67 years, respectively. Subjects of both groups participated in a three-day-per-week 20-25 min. exercise program during nine weeks. Before and after nine-week exercise program, fasting blood samples were obtained and plasma was separated. Activities of plasma glutathion peroxidase (GSH-Px) and xanthine oxidase (XO), plasma levels of nitric oxide (NO) were studied. Results: Plasma GSH-Px activity and NO level did not show any significant difference in both groups after exercise. A significant decrease was determined on XO activity of control group. XO activity of the depression group showed significant increase. XO activity of the depression group was found significantly higher than control group after exercise. There was a positive correlation between activities of XO and GSH-Px in depression group after exercise. Conclusion: It is thought that regular exercise assists in the treatment of depression as an antioxidant. (Anatolian Journal of Psychiatry 2001; 2(2):99-105)

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