Çetin KARACA, Mürüvvet BOZACI, Filiz AKYÜZ, Kadir DEMİR, Fatih BEŞIŞIK, Yılmaz ÇAKALOĞLU, Selim BADUR, Atilla ÖKTEN, Sabahattin KAYMAKOĞLU

Ülkemizdeki hepatit D virus genotipi

Bu çalışmanın amacı; hepatitis D virusu ile infekte kronik hepatitli hastalarda genotip tayini yapmaktır. Çalışma kapsamına 25 hasta alınmıştır. HDV-RNA Boom metodu, hepatitis D virusu genotip tayini ise RT-PCR ve RFLP metodu ile çalışılmıştır. 22 hastada genotip I saptanmıştır. 3 hastada genotip tayini yapılamamıştır. Sonuç olarak; ülkemizdeki hepatitis D virusu, genotip I'dir.

Anahtar Kelimeler:

Hepatit D virusu, genotip

Hepatitis D virus genotype in our country

The aim of this study was to identify hepatitis D virus genotypes in our chronic hepatitis D patients. Twenty-five patients with hepatitis D virus infection were enrolled in this study. HDV-RNA was extracted from the serum by Boom methods. Hepatitis D virus genotype was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP) methods. Genotype I was found in 22 patients, and could not be determined in the remaining 3 patients. In conclusion, genotype I is the dominant hepatitis D virus genotype in our country.

Keywords:

Hepatitis D virus, genotype,

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