FATMA EBRU AKIN, GÜLAY GÜLEÇ CEYLAN, Aylin DEMİREZER BOLAT, ÖYKÜ TAYFUR YÜREKLİ, MUSTAFA TAHTACI, Eyüp SELVİ, Naciye Şemnur BÜYÜKAŞIK, OSMAN ERSOY

Türkiye'de çölyak hastalığı ile ICAM-1 gen polimorfizminin ilişkisi

Giriş ve Amaç: Çölyak hastalığı, genetik olarak yatkın kişilerde glu- ten alımından sonra gelişen kronik intestinal inflamatuvar hastalıktır. İntersellüler adezyon molekül-1 geni, inflamatuvar olaylarda rol alan intersellüler adezyon molekül-1'i kodlamaktadır. Çölyak hastalığı olan- ların intestinal biyopsi ve serumlarında intersellüler adezyon molekül-1 seviyelerinde artış gösterilmiştir. Bu çalışmada amacımız, çölyak hasta- lığı riski ile intersellüler adezyon molekül-1 gen polimorfizminin ilişkisi- ni araştırmaktı. Gereç ve Yöntem: Çalışmaya 40 çölyak hastası ve 40 sağlıklı kontrol dahil edildi. İntersellüler adezyon molekül-1 genindeki G241R(rs1799969) polimorfizmi analiz edildi. Bulgular: Çölyak has- talığı olanlarla kontrol grubu arasında intersellüler adezyon molekül-1 geninde G241R polimorfizmi yönünden istatistiksel olarak anlamlı fark saptamadık. Sonuç: Bizim çalışmamızdaki sonuçlara göre çölyak hasta- lığında intersellüler adezyon molekül-1 G241'in rolünü gösteremedik

Association of celiac disease with an ICAM-1 gene polymorphism in Turkey

Background and Aims: Celiac disease is a chronic inflammatory dis- ease of the intestines that occurs after gluten intake in genetically sus- ceptible individuals. The intercellular adhesion molecule -1 gene codes for the intercellular adhesion molecule -1protein, which plays a pivotal role in inflammatory diseases. intercellular adhesion molecule -1 levels have been shown to be increased in celiac disease patients. We aimed to define the relationship between an intercellular adhesion molecule -1 gene polymorphism and celiac disease risk in the Turkish population. Material and Methods: Forty celiac disease patients and 40 healthy controls were included in this study. The G241 R (rs 1799969) polymor- phism was analyzed. Results: No statistically significant difference was detected in the frequency of the G241R polymorphism in the intercel- lular adhesion molecule -1 gene between celiac disease patients and healthy controls. Discussion: Further larger scale analyses are needed to support the findings of the present study

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