Hüseyin ALKIM, Sabite KACAR, Gülden AYDOĞ, Erkan PARLAK, Selçuk DİŞİBEYAZ, Perihan OĞUZ, Nurgül ŞAŞMAZ

Metoksipsöralene bağlı toksik hepatitli iki olgunun sunumu

Oral psöralenlerle birlikte ultraviyole ışığı tedavisi, psöriasis, vitiligo ve benzeri hastalıkların tedavisinde yaygın olarak kullanılmaktadır. En sık görülen yan etkiler artmış fotosensiviteye bağlı bulantı, kusma, kaşıntı ve eritemdir. Psörolanlerin hepatotoksik olmadığı ama geçici karaciğer enzim yükseklikleri yapabileceği kabul edilmektedir. Biz burada hepatotoksisite varlığını biyopsi ile gösterdiğimiz iki olguyu sunuyoruz.

Anahtar Kelimeler:

metoksipsöralen, PUVA, toksik hepatit

Methoxypsoralen-related hepatotoxicity: Two cases reports

Psoralen and ultraviolet A therapy has been widely used in the treatment of psoriasis, vitiligo and similar diseases. The most common side effects are nausea, vomiting, pruritus, and erythema, due to increased photosensitivity. It was accepted that psoralens are not hepatotoxic but can cause transient liver enzyme elevations. Here, we present two cases in which we demonstrated hepatotoxicity with biopsy.

Keywords:

Key words: Methoxypsoralen, PUVA, toxic hepatitis,

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