ENGİN ALTINTAŞ, Gönül ASLAN, Orhan SEZGİN, ENVER ÜÇBİLEK, Gürol EMEKTAŞ, Deniz GEZER

Artmış serum leptin konsantrasyonu hepatit C virüsü ile enfekte hastalarda steatozla ilişkilidir

Giriş ve Amaç: Hepatit C virüsü enfeksiyonunda steatoza yol açan mekanizma karmaşıktır. Bizim çalışmamızın amacı hepatit C virüsü ile ilgili steatozda adipositokinlerin rolünü araştırmaktır. Gereç & Yöntem: Tedavi edilmemiş genotip 1 kronik hepatit C virüslü 65 hasta adipositokinler, beden kitle indeksi, yaş, ve insulin direncinin karaciğer yağlanması ndaki etkilerini değerlendirmek için çalışmaya alındı. Bulgular: Yağlanma 31 (%47.7) hastada gözlendi. Fibroza göre adiponektin ve leptin gruplandırıldığında, adiponektin ve leptin arasında bir fark gözlemlemedik (p sırasıyla 0.597 ve 0.159). Leptin için anlamlı bir fark (p=0.021) varken, steatozlu hastalarda adiponektin düzeyleri arasında bir fark saptamadık (p=0.674). Sonuç: Hiperleptinemi kronik hepatit C virüslü hastalarda steatozun gelişimiyle ilişkilidir.

Anahtar Kelimeler:

Adiponektin, fibroz, hepatit C virüsü, insulin direnci, leptin, steatoz

Increased serum leptin concentration is related to steatosis in hepatitis C virus-infected patients

Background and Aims: The mechanism that leads to steatosis in hepatitis C virus infection is complex. The aim of our study was to search the role of adipocytokines in hepatitis C virus-related steatosis. Materials and Methods: Sixty-five untreated genotype 1 chronic hepatitis C virus patients were included in the study to evaluate the effects of adipocytokines, body mass index, age, and insulin resistance on hepatic steatosis. Results: Steatosis was observed in 31 patients (47.7%). When adiponectin and leptin were grouped according to fibrosis, we did not determine a difference between adiponectin and leptin (p values 0.597 and 0.159, respectively). We did not determine a difference in adiponectin levels in patients with different degrees of steatosis (p=0.674), while there was a significant difference for leptin (p=0.021). Conclusions: Hyperleptinemia is related to the development of steatosis in patients with chronic hepatitis C virus.

Keywords:

Adiponectin, fibrosis, hepatitis C virus, insulin resistance, leptin, steatosis,

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