Enver AKBAŞ, Reskan ALTUN, Murat KORKMAZ

Sirozlu hastalarda gelişen karaciğer dışı kanserlerin özellikleri

Giriş ve Amaç: Sirozlu hastalarda hepatosellüler karsinom görülme sıklığının artmasının yanında bazı karaciğer dışı kanserlerin görülme sıklığı da artmaktadır. Bizim merkezimizde transplantasyon öncesi takip edilen karaciğer sirozlu hastalarda karaciğer dışı kanserlerin artıp artmadığını değerlendirdik. Gereç ve Yöntem: Bu retrospektif çalışmada merkezimizde takip edilen 1017 sirozlu hastadan karaciğer dışı kanser gelişen 37 hastanın verileri değerlendirildi ve kanser insidans oranları belirlendi. Bu veriler hastanemize ait kanser insidans oranları ile karşılaştırıldı. Bulgular: Karaciğer dışı kanserlerin görülme sıklığı kontrol grubuna göre erkeklerde 4 kat, kadınlarda 9 kat, toplamda ise 7,5 kat artmış idi (p <0,05). Sirozlu hastalarda kanser türlerine göre kıyaslandığında ise lösemilerde 93 kat, lenfomalarda 33 kat, safra kesesi kanserlerinde 31 kat, mide kanserlerinde 15,5 kat, renal hücreli kanserlerde 12 kat, sarkomlarda 10 kat, mesane kanserlerinde 9 kat, pankreas, larinks, endometrium ve akciğer kanserlerinde yaklaşık 6 kat, prostat kanserlerinde 4 kat (p <0,05), kolon kanserlerinde 2,5 kat, meme kanserlerinde ise 1,2 kat artış söz konusu idi (p ˃0,05). Sonuç: Sonuç olarak sirozlu hastalarda başta lenfoma ve lösemi olmak üzere bütün karaciğer dışı kanserlerin görülme sıklığı önemli oranda artmış olarak bulundu.

Anahtar Kelimeler:

siroz, hepatosellüler karsinom, karaciğer dışı kanserler

Characteristics of non-hepatic cancers in cirrhotic patients

Background and Aims: Besides the incidence of hepatocellular carcinoma, the incidence of some non-hepatic cancers also increases in patients with cirrhosis. We evaluated whether there was an increase in the incidence of non-hepatic cancers in patients with cirrhosis diagnosed before transplantation in our center. Materials and Methods: In this retrospective study, a total sample of 1017 patients with cirrhosis who were followed up at our center was reviewed, of which the data of 37 patients who did not develop non-hepatic cancer were evaluated, and the incidence of cancer was determined. These data were compared with the incidence rate of cancer at our hospital.Results: The incidence of non-hepatic cancers was found to be increased by 4-fold in males and by 9-fold in females (overall 7.5-fold) among patients with cirrhosis compared with that in the control group (p < 0.05). Comparison based on the type of cancers in cirrhotic patients revealed an increase by 93-fold for leukemia, 33-fold for lymphoma, 31-fold for gallbladder cancers, 15.5-fold for gastric cancers, 12-fold for renal cell cancers, 10-fold for sarcomas, 9-fold for urinary bladder cancers, ~6-fold for pancreatic, laryngeal, endometrial, and lung cancers, 4-fold for prostate cancers (p < 0.05), 2.5-fold for colon cancers, and 1.2-fold for breast cancers (p ˃ 0.05). Conclusion: There was an increase in the incidence of all non-hepatic cancers, primarily lymphoma and leukemia, in patients with cirrhosis.

Keywords:

Cirrhosis, non-hepatic cancers, hepatocellular carcinoma,

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