Aylin DEMİREZER BOLAT, HÜSEYİN KÖSEOĞLU, Fatma Ebru AKIN, ÖYKÜ TAYFUR YÜREKLİ, MUSTAFA TAHTACI, Murat BAŞARAN, OSMAN ERSOY

Ortalama Eritrosit Hacim Değeri Çölyak Hastalığı Olan Hastalarda İnflamatuvar Bir Belirteç Olarak Kullanılabilir mi?

Giriş ve Amaç: Ortalama trombosit hacmi değişik hastalıklarda çalışılmış olan, basit ölçülebilen bir inflamatuvar belirteçtir. Miyokart enfarktüsü, inme gibi hastalıklarda ortalama trombosit hacminin arttığı, romatoid artrit ve ankilozan spondilit gibi inflamatuvar hastalıklarda ise ortalama trombosit hacminin azaldığı gösterilmiştir. Bu çalışmanın amacı çölyak hastalığı olan hastalarda ortalama trombosit hacmi seviyesinin değişip değişmediğinin saptanması ve glutensiz diyet tedavisi alan hastalarda tanı anındaki ortalama trombosit hacmi ile diyet sonrası ortalama trombosit hacim düzeyleri kıyaslanarak ortalama trombosit hacminin glutensiz diyete uyumun belirlenmesi için bir belirteç olarak kullanılıp kullanılamayacağının saptanmasıdır. Materyal ve Metod: Eşlik eden ciddi hastalığı olan ve glutensiz diyete yeterli şekilde uyum göstermeyen hastalar çalışmadan çıkarıldıktan sonra kalan 50 çölyak hastalığı olan hasta (erkek/kadın: 9/41) ve 50 sağlıklı gönüllü (erkek/kadın: 10/40) çalışmaya alındı ve klinik ve laboratuvar değerleri kıyaslandı. Çölyak hastalığı tanısı standart serolojik, endoskopik ve histolojik kriterlere göre konuldu. Glutensiz diyet sonrası birinci yılda klinik olarak ve serolojik olarak remisyonda olan hastaların tanı anındaki ve diyetten sonraki değerleri de karşılaştırıldı. Tam kan sayımı hastalardan kan alındıktan sonraki iki saat içinde Beckman coulter analyzer ile yapıldı. Bulgular: Çölyak hastalığı olanlar ile kontrol grubu arasında ortalama trombosit hacim düzeyi farklı saptanmadı. Çölyak grubunda da bir yıllık diyet sonrasında ortalama trombosit hacmi düzeyinde anlamlı bir değişiklik gözlenmedi, ancak diyet sonrasında tanı anına kıyasla hastaların ortalama trombosit sayısı daha düşük izlendi. Sonuç: Bu çalışma göstermiştir ki ortalama trombosit hacim düzeyinin, ne çölyak hastalığının tanısında ne de diyete uyumun bir göstergesi olarak kullanılması uygun değildir.

Anahtar Kelimeler:

Çölyak hastalığı, glutensiz diyet, ortalama trombosit hacmi

Can Serum Mean Platelet Volume be Used as an Inflammatory Marker in Patients with Celiac Disease?

Background and Aims: Mean platelet volume has been studied as a simple inflammatory marker in several diseases. Some studies have reported that mean platelet volume increases in myocardial infarction and cerebrovascular disease. Contrarily, it decreases in rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel disease. The aim of this study was to evaluate whether mean platelet volume was changed in celiac disease and whether it could be used to monitor a gluten-free diet in patients. Materials and Methods: After excluding patients with severe comorbidities and patients who did not comply with the gluten-free diet, a total of 50 patients with celiac disease (men/women: 9/41) and 50 healthy subjects (men/women: 10/40) were included in the study. The diagnosis of celiac disease was based on standard serological, endoscopic, and histological criteria. The study enrolled patients with celiac disease who recovered clinically and serologically 1 year after gluten-free diet. Complete blood count analyses were performed within 2 h after collection with the use of the Beckman coulter analyzer. Results: Mean platelet volume levels were not significantly different in the celiac disease group than that of in the control group. In the celiac disease group, the mean platelet volume levels did not change after 1 year of gluten-free diet compared with the time of celiac disease diagnosis. On the contrary, a decrease in the platelet count after gluten-free diet was detected. Conclusion: This study demonstrates that mean platelet volume is not altered in patients with celiac disease, and it also showed that mean platelet volume cannot be used as a marker for predicting dietary compliance in patients with celiac disease.

Keywords:

Celiac disease, gluten-free diet, mean platelet volume,

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