Objective: Due to few lack of researches in the field of changes of inflammatory fac- tors after post-operative knee surgery in our country in order to improve the health status of the patients, in this study, erythrocyte sedimentation rate, C-reactive pro- tein and white blood cells changes after uncomplicated arthroscopic anterior cruci- ate ligament reconstruction of the knee were investigated. Material and Methods: In this prospective experimental study, patients undergoing arthroscopic anterior cruciate ligament reconstruction of the knee with uncomplicat- ed postoperative course in Imam Hospital were studied. Results: We included 60 patients, 56 (93.3%) were male and mean age of patients was 29.58±7.15 years. C-reactive protein levels peaked on the 2 nd post-operative day and then declined and returned to the pre-operative levels on 7 th day. erythrocyte sedi- mentation rate in patients after surgery has been peaked on the 2 nd post-operative day, and returned to the pre-operative levels 14 days after surgery. The age of the patients had a direct correlation with post-operative C-reactive protein on the seventh and twenty-eighth, respectively r = 0.39, p = 0.04 and r = 0.84, p = 0.009. Patient age had a direct correlation with erythrocyte sedimentation rate day 7 and 14, respectively r = 0.49, p = 0.012; r = 0.44, p = 0.046. Conclusion: Post-operative C-reactive protein and erythrocyte sedimentation rate levels returned to pre-operative levels in days two and fourteen respectively. If C-reactive protein and erythrocyte sedimentation rate levels not reduced after the seventh and fourteenth day, respectively or increase again, definitive diagnosis of in- fection should be investigated.
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