A Comparison of Baseline Clinical Characteristics of Autoimmune Gastritis Patients with and without Type-1 Gastric Carcinoid Tumor
Objectives: Autoimmune gastritis is an antibody-mediated autoimmune disease and characterized by gastric parietal cell loss. Type-1 gastric carcinoid tumor is a disease that mostly develops on the basis of autoimmune gastritis. The aim of this study is to determine similarities and differences of baseline clinical parameters between these two disorders. Methods: Patients diagnosed as autoimmune gastritis both without gastric carcinoid tumor (n:197) and with gastric carcinoid tumor (n:40) between 2004 and 2015 at Ankara University Faculty of Medicine, Department of Gastroenterology, were included in this analysis. Data of initial signs and symptoms, basal blood count-anemia parameters, laboratory investigations, serum gastrin levels, antiparietal cell antibody status, serological helicobacter pylori markers and serum chromogranine A levels of patients were obtained, and baseline parameters of these disorders were compared Results: Patient groups were similar in age and gender. Hemoglobin, iron, total iron binding capacity, ferritin, vitamin B12 levels, antiparietal cell antibody and helicobacter pylori immunoglobulin G positivity rates and concomitant autoimmune thyroid disease prevalence were also similar. Median gastrin level in patients with autoimmune gastritis and gastric carcinoid tumors was significantly higher compared to the patients with autoimmune gastritis without gastric carcinoid tumors (807 vs. 1307 pg/ml; p:0.006). Receiver Operating Characteristic analysis revealed that a 1000 pg/ml threshold value for serum gastrin level is able to distinguish these two disorders with 65% sensitivity and 65% specificity rates (area under the curve: 0.65;p:0.006). The serum chromogranine A level did not significantly differ between patient groups. Conclusion: High serum gastrin but not chromogranine A levels may be useful in deciding which patients should be followed closely in autoimmune gastritis.
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- ISSN: 2147-9488
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 2012
- Yayıncı: HACETTEPE ÜNİVERSİTESİ
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