Funda TAMER, Mehmet Eren YÜKSEL, Gülşah AKGÜL

Yaygın kutanöz nodüller ve generalize lenfadenopati ile seyreden nadir bir sekonder sifilizli olgu

Sifiliz, bir spiroket olan Treponema pallidum’ un neden olduğu enfeksiyon hastalığıdır. Sifiliz primer, sekonder ve tersiyer sifiliz olmak üzere klinik evrelere ayrılır. Sekonder sifiliz çeşitli mukokutanöz lezyonlar ve multisistem tutulumu ile seyredebilir. Sifiliz birçok hastalığı taklit edebileceğinden ‘büyük taklitçi’ olarak bilinir. Ancak nodüler lezyonlarla seyreden sekonder sifiliz çok nadirdir. Bununla birlikte nodüler sifiliz tersiyer sifilizin nodülleri ile de karıştırılabilir. Burada, yaygın eritemli nodüller ve generalize lenfadenopati ile karakterize nadir görülen sekonder sifiliz bulguları olan 39 yaşında immünkompetan bir hasta sunduk.

A rare case of secondary syphilis presenting with extensive cutaneous nodules and generalised lymphadenopathy

Syphilis is an infectious disease caused by the spirochete Treponema pallidum. Syphilis is divided into clinical stages including primary, secondary, latent and tertiary syphilis. Secondary syphilis can present with various mucocutaneous lesions and multisystem involvement. Since it can mimic many other diseases, syphilis is known as ‘the great imitator'. However, secondary syphilis with nodular lesions is very rare. Moreover, nodular secondary syphilis can be misdiagnosed as syphilitic nodules of the tertiary stage. Hereby, we report an unusual presentation of secondary syphilis characterized by extensive erythematous nodules and generalised lymphadenopathy in an immunocompetent 39-year-old Caucasian male patient.

Keywords:

Cutaneous, Lymphadenopathy Nodule, Secondary, Syphilis,

PDF

___

1. Dave S, Gopinath DV, Thappa DM. Nodular secondary syphilis. Dermatol Online J 2003;9:9. Crossref
2. Magdaleno-Tapial J, Valenzuela-Oñate C, Ortiz-Salvador JM, Hernández-Bel P, Alegre-De Miquel V. Treponema Pallidum epidermotropism in nodular secondary syphilis. Indian J Dermatol 2018;63:509-11. Crossref
3. Hernández-Bel P, López J, Sánchez JL, Alegre V. Nodular secondary syphilis. Actas Dermosifiliogr 2009;100:520-2.
4. Veasey JV, Lellis RF, Boin MF, Porto PL, Chen JC. Papulonodular secondary syphilis: a rare clinic presentation confirmed by serologic and histologic exams. An Bras Dermatol 2016;91:205- 7. Crossref
5. Dupnik KM, Martins MM, Souza AT, Jerônimo SM, Nobre ML. Nodular secondary syphilis simulating lepromatous leprosy. Lepr Rev 2012;83:389-93.
6. Lee GL, Gru AA, Wong HK, Nagarajan P. Granulomatous syphilis: a pattern to remember. case report and review of literature. Clin Microbial 2015;4:184. Crossref
7. Li F, Wang T, Wang L. Secondary syphilis primarily presenting with multiple nodules on the scalp: case report and published work review. J Dermatol 2017;44:1401-3. Crossref
8. WHO Guidelines for the treatment of Treponema pallidum (Syphilis). Geneva: World Health Organization; 2016. 4, Recommendations for treatment of syphilis. Available from: https://www.ncbi.nlm.nih.gov/books/NBK384905/
9. Ghafoor R, Anwar MI. A young boy with persistent nodules and hoarseness: a rare presentation of nodular secondary syphilis. J Coll Physicians Surg Pak 2018;28:37-8.
10. Edwards B, Vaughan S. HIV testing: support for routine screening. CJGIM 2015;10:20-3.