Obstrüktif Uyku Apne Sendromu OUAS Saptanan Hastalarda Vasküler Fonksiyon Bozukluğu ve Ateroskleroz Riskinin Değerlendirilmesi

Amaç: Obstrüktif Uyku Apne Sendromu OUAS saptanan hastalarda vasküler endoteliyel işlev bozukluğu ve preaterosklerozis; brakial arter akım aracılı vazodilatasyon BAAV , karotis arter intima-media kalınlığı KIMK , mean platelet volume MPV ve epikardiyal yağ dokusu EYD ölçümü yapılarak değerlendirildi. OUAS hastaları Apne-hipopne indekslerine AHI göre gruplara ayrılarak kıyaslandı. Hastalar ve Yöntem:Hastanemize uyku bozukluğu nedeni ile başvuran ve polisomniografi ile yapılan değerlendirmede AHİ değeri 5 ve üstünde bulunan, hiperlipidemi, hipertansiyon, diyabetes mellitus ve bilinen kalp-damar hastalığı olmayan, yaşları 30-70 arası, kadın ve erkeklerden oluşan hastalar çalışmaya dahil edildi. Bu hastalar AHI derecelerine göre hafif-orta ve şiddetli şeklinde gruplandırıldı. Preateroskleroz KIMK, EYD kalınlığı ve MPV ile vasküler fonksiyon ve endotel hücre vazodilatasyonu ise BAEF bakılarak değerlendirildi. İstatistik olarak iki grup arasındaki farklılıklar değerlendirilmek istendiğinde parametrik test ön şartlarını sağladığı durumda “Student’s t Test”; sağlamadığında ise “Mann Whitney–U testi” kullanıldı. Bulgular: 23 hastanın 16 tanesi erkek, 7 tanesi kadındır. Yaş ortalaması 46,30+9,51 31-65 yaş arası . Hastalar AHI indekslerine göre hafif:5-15, orta:16-30, şiddetli >30 olarak gruplandırıldığında karşılaştırma için kullanılan parametrelerde anlamlı farklılık saptanmadı. Sonuç: OUAS hastalarında kardiyovasküler riskin arttığı bilinmektedir. Çalışmamızda bu hastalarda hastalığın şiddeti ile preateroskleroz ve endotel fonksiyonun bozulması arasında bağlantı bulunmamıştır

Investigation of Endothelial Dysfunction and The Risk of Atherosclerosis In Patients With Obstructive Sleep Apnea Syndrome

Purpose: To investigate endothelial dysfunction and pre-atherosclerosis in patients with Obstructive Sleep Apnea Syndrome OSAS by using several parameters including Brachial Artery Flow-Mediated Vasodilation BAFMV , Carotid Intima-Media Thickness CIMT , Mean Platelet Volume MPV and Epicardial Fat Thickness EFT . Patients with OSAS were classified according to the Apnea-Hypopnea Index AHI . Patients and Methods: OSAS patients who have 5 or more AHI score were enrolled in the study. Patients with hypertension, hyperlipidemia, diabetes mellitus and cardiovascular diseases were excluded. Patients were classified as mild 5-10 , moderate 16-30 and severe >30 according to AHI. These groups were compared to each other in terms of endothelial dysfunction and pre-atherosclerosis markers including BAFMV, CIMT, MPV and EFT. Groups were compared statistically by using either Student’s T-Test or Mann Whitney–U test. Results: Our study population consists of 23 patients with OSAS 16 male, 7 female with the mean age of 46.30±9.51 years ranging from 31-65 years. There were no significant differences in all parameters between the mild 5-10 , moderate 16-30 and severe >30 groups according to AHI. Conclusion: It is well known that patients with OSAS have an increased cardiovascular risk. In our study, no differences were shown between the progression of the disease and endothelial dysfunction and pre-atherosclerosis markers.

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Karadağ M, Yavuz Z. Uyku Apne Sendromu. Erişim: http:// uykubozuklugu.uludag.edu.tr/literatur1.htm

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Acıbadem Üniversitesi Sağlık Bilimleri Dergisi-Cover
  • ISSN: 1309-470X
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2010
  • Yayıncı: ACIBADEM MEHMET ALİ AYDINLAR ÜNİVERSİTESİ