ÖZGÜR KOŞKAN, FATİH AKSOY, Başak TEMELLİ, Zuhal Yetkin AY, ERCAN VAROL

Periodontitisle ilişkili sistemik inflamatuvar yük ve ileride oluşabilecek kardiyovasküler olay riski arasında korelasyon var mı? Ön bulgular Prof. Zuhal Yetkin Ay

Amaç: Periodontitis (P) ve koroner arter hastalığı (KAH) arasındaki ilişkinin doğrudan bir bir ilişki mi yoksa "neden-sonuç" ilişkisi mi olduğunu belirlemek, bu iki inflamatuvar hastalığın multifaktöriyel doğasından ötürü zordur. Bu çalışmanın amacı periodontitis ile ilişkili sistemik inflamatuvar yüklenme ile ileride oluşabilecek kardiyovasküler olay riski ile bir korelasyonu olduğu hipotezini test etmektir. Gereç ve Yöntem: Yaşları 30-75 arasında değişen, KAH şüphesiyle koroner anjiyografi uygulanacak olan hastalar çalışmaya dahil edildi. Katılımcılar şu dört alt gruba ayrıldı: Grup 1: KAH (+) P (+) (n=20), Grup 2: KAH (+) P (-) (n=20), Grup 3: KAH (-)P (+) (n=21), Grup 4: KAH (-) P (-) (n=16). Klinik periodontal parametreler ve periodontal inflame yüzey alanı (PİYA) kayıtları alındı. Gruplar arası farkların belirlenmesinde parametrik olan (Varyans analizi ve Tukey) ve olmayan (Kruskall-Wallis ve Bonferonni-Dunn) testleri; korelasyonların incelenmesinde ise Pearson korelasyon analiz testi kullanıldı (p

Is there a correlation between the periodontitis-related systemic inflammatory burden and future cardiovascular events’ risk? A preliminary report

Aim: To define a direct relationship or “cause-effect” relationship between the periodontitis and coronary artery disease (CAD) is hard due to the multifactorial nature of both inflammatory diseases. This study was aimed to test the hypothesis whether periodontitis related systemic inflammatory burden have a correlation with the future cardiovascular events. Materials and Methods: Patients who undergo for coronary angiography with suspicion of coronary artery disease (CAD) between the ages 30-75 were included. The participants were divided into four groups: Group 1: CAD (+) P (+) (n=20), Group 2: CAD (+) P (-) (n=20), Group 3: CAD (-) P (+) (n=21), Group 4: CAD (-) P (-) (n=16). Clinical periodontal parameters and the periodontal inflamed surface area (PISA) were recorded. The parametric (analysis of variance, Tukey test) and non-parametric (Kruskall-Wallis and Bonferonni-Dunn) tests were used to determine the differences among the groups. The correlations between the parameters were tested with Pearson correlation analysis (p

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