Ogül Leman TUNAR, Gizem İNCE KUKA, Hazel Zeynep KOCABAŞ, Ebru Özkan KARACA, Hare GÜRSOY, Bahar KURU

Halitosis: Periodontal hastalıklarla ilişkisi ve tedavi stratejileri

Halitosis terimi, konuşurken veya soluma yolu ile oral kaviteden yayılan hoş olmayan ağız kokusu olarak tanımlanmaktadır. Halitosis, patolojik veya patolojik olmayan nedenlerle gelişebilen, ağız içi veya ağız dışı bir kaynaktan kötü koku yayılmasına neden olan uçucu bileşiklerin gelişmesini ifade etmektedir. 2014 yılında yapılmış olan son halitosis sınıflamasına göre 6 farklı tip belirlenmiştir. Halitosis prevelansının %22 ile %50 arasında olduğu bildirilmiş olsa da halitosis görülme sıklığı ve tedavisini içeren az sayıda çalışma olması, bu konuda yapılacak çalışmalara olan ihtiyacı ortaya koymaktadır. Bu derlemede halitosis tanımı, sınıflandırılması, etiyolojisi ve güncel tedavi yaklaşımlarına değinilmiştir.

Halitosis: Relationship with periodontal diseases and treatment strategies

Halitosis is defined as an unpleasant odour originating from mouth during speaking or exhalation. Halitosis may be pathological or unpathological which leads to the formation of volatile compounds from an intra or extra oral source. According to a recent classification in 2014, 6 different types of halitosis have been defined. Although the prevelance of halitosis has been reported between 22- 50%, limited number of studies are available regarding the prevelance and treatment strategies. Therefore in this review, definition of halitosis, classification as well as the current treatment options have been disscussed.

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1. Scully C, Greenman J. Halitology Breath odour: aetiopathogenesis and management. Oral diseases 2012; 18: 333-345.
2. De Geest S, Laleman I, Teughels W, Dekeyser C, Quirynen M. Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists. Periodontology 2000 2016; 71: 213-227.
3. Tonzetich J. Production and origin of oral malodor: a review of mechanisms and methods of analysis. Journal of periodontology 1977; 48: 13-20.
4. Miyazaki H AM, Okamura K, KawaguchiY, Toyofuku A, Hoshi K, Yaegaki K. Tentative classification of halitosis and its treatment needs. Niigata Dental Journal 1999; 32: 7-11.
5. Tangerman A, Winkel E. Extra-oral halitosis: an overview. Journal of breath research 2010; 4: 017003.
6. Aydin M, Harvey-Woodworth C. Halitosis: a new definition and classification. British dental journal 2014; 217: E1.
7. Cortelli JR, Barbosa MDS, Westphal MA. Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research 2008; 22: 44-54.
8. Mariotti A. Dental plaque-induced gingival diseases. Annals of periodontology 1999; 4: 7-17.
9. Albandar JM, Rams TE. Global epidemiology of periodontal diseases: an overview. Periodontology 2000 2002; 29: 7-10.
10. Chapple IL, Van der Weijden F, Doerfer C, et al. Primary prevention of periodontitis: managing gingivitis. Journal of clinical periodontology 2015; 42.
11. Durham J, Fraser HM, McCracken GI, Stone KM, John MT, Preshaw PM. Impact of periodontitis on oral health-related quality of life. Journal of dentistry 2013; 41: 370-376.
12. Tonzetich J, Kestenbaum R. Odour production by human salivary fractions and plaque. Archives of oral biology 1969; 14: 815-827.
13. Persson S, Edlund MB, Claesson R, Carlsson J. The formation of hydrogen sulfide and methyl mercaptan by oral bacteria. Molecular Oral Microbiology 1990; 5: 195- 201.
14. Khaira N, Palmer R, Wilson R, Scott D, Wade W. Periodontal Disease: Production of volatile sulphur compounds in diseased periodontal pockets is significantly increased in smokers. Oral diseases 2000; 6: 371-375.
15. Loesche WJ, Kazor C. Microbiology and treatment of halitosis. Periodontology 2000 2002; 28: 256-279.
16. Bosy A, Kulkarni G, Rosenberg M, McCulloch C. Relationship of oral malodor to periodontitis: evidence of independence in discrete subpopulations. Journal of periodontology 1994; 65: 37-46.
17. DE BOEVER EH, Loesche WJ. Assessing the contribution of anaerobic microflora of the tongue to oral malodor. The Journal of the American Dental Association 1995; 126: 1384-1393.
18. Morita M, Wang H-L. Relationship between sulcular sulfide level and oral malodor in subjects with periodontal disease. Journal of periodontology 2001; 72: 79-84.
19. Liu XN, Shinada K, Chen XC, Zhang BX, Yaegaki K, Kawaguchi Y. Oral malodor‐related parameters in the Chinese general population. Journal of clinical periodontology 2006; 33: 31-36.
20. Miyazaki H, Sakao S, Katoh Y, Takehara T. Correlation between volatile sulphur compounds and certain oral health measurements in the general population. Journal of periodontology 1995; 66: 679-684.
21. Quirynen M, Dadamio J, Van den Velde S, et al. Characteristics of 2000 patients who visited a halitosis clinic. Journal of clinical periodontology 2009; 36: 970-975.
22. Ratcliff PA, Johnson PW. The relationship between oral malodor, gingivitis, and periodontitis. A review. Journal of periodontology 1999; 70: 485-489.
23. Ng W, Tonzetich J. Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosa. Journal of Dental Research 1984; 63: 994-997.
24. Schroeder H, Münzel-Pedrazzoli S, Page R. Correlated morphometric and biochemical analysis of gingival tissue in early chronic gingivitis in man. Archives of oral biology 1973; 18: 899IN11923-11922IN11912.
25. Rosenberg M. Clinical assessment of bad breath: current concepts. The Journal of the American Dental Association 1996; 127: 475-482.
26. Rosenberg M, Septon I, Eli I, et al. Halitosis measurement by an industrial sulphide monitor. Journal of periodontology 1991; 62: 487-489.
27. Quirynen M, Zhao H, Avontroodt P, et al. A salivary in cubation test for evaluation of oral malodor: a pilot study. Journal of periodontology 2003; 74: 937-944.
28. Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. JOURNAL-CANADIAN DENTAL ASSOCIATION 2000; 66: 257- 261.
29. Salako NO, Philip L. Comparison of the use of the Halimeter and the Oral Chroma™ in the assessment of the ability of common cultivable oral anaerobic bacteria to produce malodorous volatile sulfur compounds from cysteine and methionine. Medical Principles and Practice 2011; 20: 75-79.
30. Goldberg S, Kozlovsky A, Gordon D, Gelernter I, Sintov A, Rosenberg M. Cadaverine as a putative component of oral malodor. Journal of dental research 1994; 73: 1168-1172.
31. Burton J, Chilcott C, Moore C, Speiser G, Tagg J. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. Journal of applied microbiology 2006; 100: 754-764.
32. Reingewirtz Y, Girault O, Reingewirtz N, Senger B. Mechanical effects and volatile sulfur compound--reducing effects of chewing gums: Comparison between test and base gums and a control group. Quintessence international 1999; 30.
33. Sterer N, Rubinstein Y. Effect of various natural medicinals on salivary protein putrefaction and malodor production. Quintessence International 2006; 37.
34. Dadamio J, Tournout M, Teughels W, Dekeyser C, Coucke W, Quirynen M. Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial. Journal of clinical periodontology 2013; 40: 505-513.
35. Kleinberg I, Wolff M, Codipilly D. Role of saliva in oral dryness, oral feel and oral malodour. International dental journal 2002; 52: 236-240.
36. Quirynen M, Avontroodt P, Soers C, Zhao H, Pauwels M, Van Steenberghe D. Impact of tongue cleansers on microbial load and taste. Journal of clinical periodontology 2004; 31: 506-510.
37. Pedrazzi V, Sato S, de Mattos MdGC, Lara EHG, Panzeri H. Tongue-cleaning methods: a comparative clinical trial employing a toothbrush and a tongue scraper. Journal of periodontology 2004; 75: 1009-1012.
38. Bollen CM, Quirynen M. Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. Journal of periodontology 1996; 67: 1143-1158.
39. Renton-Harper P, Addy M, Moran J, Doherty F, Newcombe R. A comparison of chlorhexidine, cetylpyridinium chloride, triclosan, and C31G mouthrinse products for plaque inhibition. Journal of periodontology 1996; 67: 486-489.
40. Van Leeuwen M, Slot D, Van der Weijden G. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. Journal of periodontology 2011; 82: 174-194.
41. Fedorowicz Z, Aljufairi H, Nasser M, Outhouse TL, Pedrazzi V. Mouthrinses for the treatment of halitosis. Cochrane Database Syst Rev 2008; 4.
42. Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Kawaguchi Y. A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor. Trials 2008; 9: 71.
43. Lynch E, Sheerin A, Claxson AW, et al. Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (CIO2). Free radical research 1997; 26: 209-234.
44. Aung EE, Ueno M, Zaitsu T, Furukawa S, Kawaguchi Y. Effectiveness of three oral hygiene regimens on oral malodor reduction: a randomized clinical trial. Trials 2015; 16: 31.
45.Young A, Jonski G, Rölla G, Wåler S. Effects of metal salts on the oral production of volatile sulfur‐containing compounds (VSC). Journal of clinical periodontology 2001; 28: 776-781.
46. Chatterjee A, Bhattacharya H, Kandwal A. Probiotics in periodontal health and disease. Journal of Indian society of periodontology 2011; 15: 23.
47. Jamali Z, Aminabadi NA, Samiei M, Deljavan AS, Shokravi M, Shirazi S. Impact of Chlorhexidine Pretreatment Followed by Probiotic Streptococcus salivarius Strain K12 on Halitosis in Children: A Randomised Controlled Clinical Trial. Oral health & preventive dentistry 2016; 14.
48. Lee S-H, Baek D-H. Effects of Streptococcus thermophilus on volatile sulfur compounds produced by Porphyromonas gingivalis. Archives of oral biology 2014; 59: 1205-1210.
49. Penala S, Kalakonda B, Pathakota KR, et al. Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: A randomized controlled trial. Journal of research in pharmacy practice 2016; 5: 86.