Yıl 2009, Cilt: 1 Sayı : 3 Sayfalar 90 - 94 2013-08-13
Contraceptive Effects of Onosma armeniacum on Embryo Implantation in Rats
Suleyman Salman,Serkan Kumbasar,Ufuk Ozgen,Fazli Erdogan,Halis Suleyman
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Öz O. armeniacum has traditionally been used to heal wounds, burns, dyspnea, hoarseness, hemorrhoids, abdominalaches, stomach ulcers, and gynecological problems. In this study, the embryotoxic and contraceptiveeffect of Onosma armeniacum root extract (A-1) was investigated in female rats.Group 1: 100 mg/kg A-1 for seven days beginning at the previous day of the mating period. Group 2: 100mg/kg A-1 for seven days beginning at first day of the mating period. Group 3: 100 mg/kg A-1 for seven daysbeginning 48 hours after the mating period Group 4: 100 mg/kg A-1 for seven days beginning 120 hoursafter the mating period rats. Group 5: Sunflower oil + 3 days mating period (Control group). Also histopathologicalexaminations were performed on ovary and uterus of A-1 given rats.Histopathology of ovary and uterus in the rats were not affected by A-1 supplementation.A-1 did not induce toxic effect on embryo although it induced contraceptive effects on the embryo implantationin the rats. Shikonin content of the A-1 may be responsible on the contraceptive effect in the rats.

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Yayımlanma Tarihi 13 Ağustos 2013
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Yayımlanma Tarihi : 13 Ağustos 2013


Makalenin Yazarları
Suleyman Salman
Serkan Kumbasar
Ufuk Ozgen
Fazli Erdogan
Halis Suleyman