Endometrium kanserinde nötrofil/lenfosit oranının ve platelet endekslerinin değerlendirilmesi

Amaç: Jinekolojik kanserler arasında en sık görüleni endometrium kanseridir. Tüm kanserlerde olduğu gibi, endometrium kanserinde de kronik inflamasyon etyolojik faktör olarak rol oynamaktadır. Gereç ve Yöntem: Çalışmamıza her grupta 35 olmak üzere üç grup ve toplam 105 hasta dahil edildi. Endometrial örnekleme sonuçlarına göre gruplar; benign grup, hiperplazi grubu ve malign grup olarak isimlendirildi. Gruplar arasında hematolojik parametrelerde anlamlı fark olup olmadığı araştırıldı.Bulgular: Nötrofil sayısı, lenfosit sayısı, platelet sayısı, nötrofil/lenfosit oranı ve platelet/lenfosit oranı bakımından gruplar arasında istatistiksel olarak anlamlı bir fark saptanmadı (p>0,05). Hemoglobin, ortalama platelet volümü ve Platelet dağılım genişliği değerleri malign grupta istatistiksel olarak anlamlı derecede yüksek saptandı (p<0,05). Sonuç: Çalışmamızda elde ettiğimiz sonuçlar bize; inflamasyonun, platelet aktivitesini arttırarak endometrium kanserine zemin hazırlayabileceğini düşündürdü.

Anahtar Kelimeler:

Endometrium kanseri, nötrofil/lenfosit oranı, ortalama platelet volümü

Evaluation of neutrophil / lymphocyte ratio and platelet indexes in endometrium cancer

Aim: Endometrium cancer is the most commonly seen gynecologic cancer. As in all the cancer processes, chronic inflammation plays an etiological role. Material and Method: The study included a total of 105 patients. Three groups each consisting 35 patients are formed. Based on the results of endometrial sampling, the patients are groped as benign, hyperplasia and malignant. Differences of hematologic parameters between the groups were investigated.Results: There was no statistically significant difference between the groups in terms of neutrophil, lymphocyte, and platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio (p>0.05). Hemoglobin, mean platelet volume and platelet distribution width values were found statistically significantly higher in the malignant group (p<0.05). Conclusion: As a result; inflammation may increase platelet activity and provide a basis for endometrial cancer.

Keywords:

Endometrium cancer neutrophil/lymphocyte ratio, mean platelet volume, platelet distribution width,

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