Mehmet Ata AKIL, Mehmet Zihni BİLİK, Halit Acet, Senem YAMAN TUNÇ, Faruk ERTAŞ, Mesut AYDIN, Hasan KAYA, Yahya İSLAMOĞLU, Sait ALAN

Ortalama Trombosit Hacmi ve Nötrofil Lenfosit Oranı: Preeklampsinin Ciddiyetinin Yeni Belirteçleri

Giriş: Bu çalışmada, hematolojik parametrelerin ölçümleri ile preeklamptik kadınlarda hipertansiyon şiddetini tahmin etmenin mümkün olup olmadığını araştırdık. Hastalar ve Yöntem: İki yüz altmış bir preeklamptik ve 51 normal gebe kadın çalışmaya alındı. Preeklampsi olguları hafif ve ağır preeklampsi olarak sınıflandırıldı. Bulgular: Doğum sonrası sonuçlar karşılaştırıldığında, preeklamptik kadınların trombosit sayıları düşük, ortalama trombosit hacimleri ve nötrofil lenfosit oranları yüksekti (sırasıyla; p< 0.001, p< 0.001 ve p< 0.001). Çoklu lineer regresyon analizinde, ortalama trombosit hacmi ve nötrofil lenfosit oranı hipertansiyon şiddeti ile bağımsız bir şekilde korelasyon gösterdi (sırasıyla; β= 0.25, p< 0.001 ve β= 0.31, p< 0.001). Sonuç: Hem ortalama trombosit hacmi hemde nötrofil lenfosit oranı preeklamptik gebelerde hipertansiyonun şiddetini öngörmede bağımsız birer belirleyici olarak kullanılabilir.

Anahtar Kelimeler:

Preeklampsi, ortalama trombosit hacmi, nötrofil lenfosit oranı, hipertansiyon

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Introduction: This study was undertaken to examine the role of hematological parameters in predicting the severity of hypertension in pre-eclamptic women. Patients and Methods: Two hundred sixty-one pre-eclamptic women and fifty-one women with normal pregnancy were included in the study. The severity of preeclampsia was classified as mild or severe. Results: Compared to post-delivery period, pre-eclamptic females had lower platelet count, raised mean platelet volume and raised neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001, respectively). Multiple linear regression analysis showed an independent correlation between the severity of hypertension and mean platelet volume as well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p< 0.001, respectively). Conclusion: Both mean platelet volume and neutrophil lymphocyte ratio emerged as independent predictors of the severity of hypertension in preeclampsia.

Keywords:

Preeclampsia, mean platelet volume, neutrophil lymphocyte ratio, hypertension,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi