İsmail UNGAN, Ersan OFLAR, Alparslan ŞAHİN, Esra DÖNMEZ İŞLER, Mustafa Hakan ŞAHİN, Vusal KHANKİSHİYEV, Atilla KOYUNCU, Alev KURAL

Kardiyak Sendrom X’li Hastalarda Epikardiyal Yağ Dokusu Kalınlığının ve Serum Omentin Seviyelerinin Değerlendirilmesi

Giriş: Bu çalışmanın amacı kardiyak sendrom X’li hastalarda epikardiyal yağ dokusu ile serum omentin seviyeleri arasındanki ilişkiyi değerlendirmektir. Hastalar ve Yöntem: Kliniğimizde tanısı konan 51 kardiyak sendrom X hastası, hasta grubuna ve 46 sağlıklı olgu ise kontrol grubuna dahil edilmiştir. Demografik veriler, rutin labarotuvar testleri hsCRP seviyeleri çalışıldı. Epikardiyal yağ dokusu kalınlığı transtorasik ekokardiyografi ile serum omentin seviyeleri ise ELISA yontemi ile ölçüldü. Bulgular: Epikardiyal yağ dokusu kalınlığı hasta grubunda anlamlı olarak daha kalındı (p< 0.001). Kontrol grubu ile karşılaştırıldığında, serum omentin seviyeleri hasta grubunda anlamlı olarak daha düşüktü (p< 0.001). Kardiyak sendrom X’li hastalarda medyan yaş anlamlı olarak daha yüksekti (p< 0.001). Lökosit sayımı ve hsCRP seviyleri iki grup arasından anlamlı farklılık göstermedi (sırasıyla; p= 0.46, p= 0.49 ) Sonuç: Güncel literatüre benzer şekilde, yapmış olduğumuz çalışmamızda, kardiyak sendrom X’li hastalarda epikardiyal yağ dokusu kalınlığının artmış ve serum omentin seviyelerinin düşük olduğunu gösterdik. Bu bulgular ışığında artmış epikardiyal yağ dokusu, serum omentin seviyelerindeki düşüşe neden olarak koroner sendrom X hastalığının patolojisinde rol oynayabilir.

Anahtar Kelimeler:

Epikardiyal yağ dokusu, omentin, kardiyak sendrom X

Evaluation of the Epicardial Fat Tissue Thickness and Serum Omentin Levels in Patients with Cardiac Syndrome X

Introduction: The aim of this study was to evaluate the correlation between the epicardial fat tissue thickness (EFTT) and serum omentin levels in patients with cardiac syndrome X (CSX). Patients and Methods: A total of 51 patients with CSX admitted to our clinic were included in the patient group, and 46 healthy subjects were included in the control group. Demographics, routine laboratory tests, and high sensitive C-reactive protein (hsCRP) levels of all patients were recorded. The EFTT was measured with transthoracic echocardiography (TTE). Serum omentin levels were measured with the enzyme-linked immunosorbent assay. Results: The EFTT was significantly higher in the CSX group (p< 0.001). Serum omentin levels were significantly lower in patients with CSX in comparison with the control group (p< 0.001). The median age was significantly higher in the CSX group (p< 0.001). The white blood count and hsCRP levels showed no significant difference between the CSX and the control group (p= 0.46 and p= 0.49, respectively). Conclusion: In our study, we found increased epicardial fat tissue (EFT) thickness and decreased serum omentin levels in patients with CSX, a finding similar with the literature. Thus, increased EFT thickness may play a role in the pathophysiology of CSX by causing a decrease in the serum omentin level.

Keywords:

Epicardial fat tissue, omentin, cardiac syndrome X,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi