Oruç Alper ONK, Mehmet AKSÜT, Fatih ÖZÇELİK, Didem ONK, Erdim SERTOĞLU, Hüseyin Serkan EROL, Ümit KAHRAMAN, Osman Nuri TUNCER, Ömer YİĞİNER, Bilgehan ERKUT

Ankaferd® Kanama Durdurucunun Rat Abdominal Aort Kanama Modelinde Kanama Zamanına Etkisi

Giriş: Topikal hemostatik ajanların birçok cerrahi alanda kullanımı son yıllarda popularite kazanmıştır. Ankaferd® kanama durdurucu (ABS) ajanın ratlarda abdominal aort cerrahisinde kanama zamanını kısaltıp, kanama miktarını azaltabildiğini belirt meye amaçladık. Hastalar ve Yöntem: Toplam 40 rat random 4 gruba (her grup n= 10) ayrıldı. Grup 1 ve grup 2’deki ön-tedavi almayan ratlara salin ve Ankaferd kanama durdurucu ABS emdirilmiş gaz uygulanırken, 5 gün asetil salisilik asit ve klopidgrel tedavisi alış olan grup 3 ve 4’teki ratlara da salin ve ABS emdirilmiş gaz uygulandı. İliak bifurkasyonun üzerinde abdominal aortaya 1 mm’lik bir kesi yapıldı. Ortalama kanama zamanı ve ortalama kanama miktarı belirlenip karşılaştırıldı. Bulgular: Ratların yaş, ağırlık ve laboratuvar sonuçları karşılaştırıldığında gruplar arası anlamlı farklılık yoktu. ABS emdirilmiş gaz kullanılan hem tedavi uygulanmış hem de tedavi uygulanmamış gruplarda daha kısa kanama zamanı ve daha az kanama miktarı tespit edildi. Aradaki fark istatistiksel olarak anlamlı bulundu. Sonuç: Ankaferd® kanama durdurucunun major aort cerrahisi sonrası daha kısa kanama zamanı sağlama ve operasyon sonrası daha az kan kaybı sağlama potansiyeline sahiptir.

Anahtar Kelimeler:

Topikal hemostaz, abdominal aort

Haemostatic Effects of Topical Ankaferd Blood Stopper® On Bleeding Time in A Rat Abdominal Aortic Bleeding Model

Introduction: The use of topical haemostatic agents has been popularised in recent years in many areas of surgery. We aimed to determine whether Ankaferd blood stopper® (ABS) can shorten the bleeding time and decrease the amount of bleeding in a rat abdominal aortic bleeding model. Patients and Methods: A total of 40 rats were randomly divided into four groups (n= 10 in each group). Saline- and ABS-soaked gauzes were applied to rats that had not received any pre-treatment in Groups 1 and 2, while saline- and ABS-soaked gauzes were applied to rats that had received acetylsalicylic acid plus oral clopidrogel for 5 days in Groups 3 and 4. An incision of about 1 mm was made over the aorta just proximal to the iliac bifurcation. Mean bleeding time (MBT) and mean bleeding amount (MBA) were determined and compared. Results: There were no significant differences in the age, weight and blood sample laboratory results of rats. Shorter MBT and less MBA were determined in ABS-soaked groups and the differences were statistically significant. Conclusion: Ankaferd blood stopper® has the potential to reduce the bleeding time and post-operative blood loss after a major aortic surgery.

Keywords:

Topical haemostasis, abdominal aorta,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi