Ukeme Gideon ETUK, Paul Columba INYANG-ETOH, Mfonisa İniobong UDONKANG, Emmanuel Monday Japhet, Uloma Opara-Osuoha
Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community
Objective: Urogenital schistosomiasis has continued to cause
severe morbidity among residents of Adim community. The aim of the study was to
screen both adults and children residents of this community for urine tumour
markers and to stain cytologically for epithelial changes which indicate the
risk of them being predispose to bladder cancer.
Methods: Terminal
urine samples were collected by simple random sampling method from 350 subjects
(300 children and 50 adults) in Adim Community for microscopy using standard
parasitological methods, urinalysis, ELISA-based Nuclear Matrix Protein 22
(NMP22), and Papanicolaou- and Alcian blue-stained cytological analysis.
Results: S. haematobium infection was observed in 18 (5.1%), proteinuria 21
(6.0%) and hematuria 30 (8.6%). Age group 25-31 years had the highest level of
NMP22 values (1692.3 ± 46.4) among the adults and children. The difference was
statistically significant (P=0.001). In general male subjects had higher NMP22
values (1214.6+ 487.1) than females (1198.9+ 472.9) (P=0.389). The cytological
findings showed abnormal epithelial cells in Papanicolaou stain 2 (0.57%) and
hyaluronic acid 1 (0.29%). Cytological findings with Papanicolaou stain
revealed metaplasia 1 (0.3%), mild dysplasia 1 (0.3%), inflammation 6 (1.7%),
and hyaluronic acid positive cells 1 (0.29%).
Conclusion: The study showed S.
haematobium prevalence of 5.1% but NMP 22 values were not positive for
bladder cancer. The cytological findings revealed metaplasia, mild dysplasia
and hyaluronic acid positive epithelial changes which are indicators for
bladder cancer. J Microbiol Infect Dis
2018; 8(3):89-96
___
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- ISSN: 2146-3158
- Başlangıç: 2011
- Yayıncı: Sağlık Araştırmaları Derneği
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