Objective: Group A Streptococci (GAS) are the most important bacterial cause of pharyngitis. Antibiotic therapy canbe prescribed and failure to treat it is associated with suppurative and nonsuppurative complications. Nonsuppurativecomplications occur after a latency period of a few weeks and include acute rheumatic fever, scarlet fever, streptococcaltoxic shock syndrome, acute glomerulonephritis, and pediatric autoimmune neuropsychiatric disorder associated withgroup A streptococci. The aim of this study is to investigate the frequency of nonsuppurative complications in properlytreated children with GAS pharyngitis.Methods: We investigated the frequency of nonsuppurative complications in 1030 proven GAS pharyngitis patients between5 and 15 years old, who were properly treated by a prospective observational study. All patients diagnosed withGAS pharyngitis were followed up prospectively using a standard form for six months made by monthly phone calls.Results: All the isolates recovered from the patients were susceptible to penicillin. Twentyseven (2.6%) patients developedscarlet fever. No other nonsuppurative complications occured in our patient cohort.Conclusions: Penicillin remains the drug of choice for treatment of GAS pharyngitis. The rate of nonsuppurative co
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