MİDE KANSERİ HASTALARINDA PERİFERİK KAN SAYIMI İLE PROGNOZ ARASINDAKİ İLİŞKİ

Amaç: Birçok kanserde olduğu gibi mide kanserinde de hastalığın seyrini tanı anında öngörmek tedavi stratejisini belirlemede önemli yer tutmaktadır. Son yıllarda tam kan sayımı parametreleriyle kanserler arasında prognoz açısından ilişki olabileceği konusunda birçok çalışma yapılmıştır. Çalışmamızda hastaların tanı anındaki nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve eritrosit dağılım aralığı (RDW) değerlerinin sağkalım ile olan ilişkisini değerlendirdik. Gereç ve Yöntem: Çalışmaya Ondokuz Mayıs Üniversitesi Tıp Fakültesi Tıbbı Onkoloji kliniğinde Ocak 2006 ile Eylül 2014 tarihleri arasında yeni tanı almış, tedavi ve takipleri merkezimizde yapılan mide kanseri hastaları dahil edildi. Çalışmaya 201 hasta alınmış olup, evre 1-2-3 olanlar Grup A (n=122) ve evre 4 olanlar Grup B (n=79) olmak üzere 2 gruba ayrıldı. Gruplar ile NLR, PLR ve RDW arasındaki sağ kalım ilişkisi yaşam analizi ile değerlendirildi. Bu parametreler için ROC analizi kullanılarak cut-off değerleri bulundu. Bulgular: Çalışmada bahsedilen parametreler ile mide kanseri hastalarının sağkalımları arasındaki ilişki incelendiğinde; NLR’nin artmasıyla yaşam sürelerinin anlamlı ölçüde kısaldığı ve dolayısıyla prognozun daha kötü olduğu istatistiksel olarak gösterildi (p<0,05). PLR ve RDW ile hastaların sağkalımları arasında anlamlı ilişki yoktu. Sonuç: Mide kanserinde tanı anındaki NLR ile prognoz ve sağkalım arasında istatistiksel olarak ilişki olup, bu oran arttıkça sağkalım oranları azalmakta ve prognoz daha kötü olmaktadır.

Anahtar Kelimeler:

Mide kanseri, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, eritrosit dağılım aralığı

THE RELATIONSHIP BETWEEN PERIPHERAL BLOOD COUNT AND PROGNOSIS IN PATIENTS WITH GASTRIC CANCER

Objective: Like in many types of cancer, predicting the course of the illness at the moment of diagnosis has an important place in determining the treatment strategy. Recently, there have been a great number of studies which indicate that there may be a relationship between total blood count parameters and cancers in terms of prognosis. In our study, we assessed the relationship between survival and the patients’ neutrophil-lymphocyte ratio (NLR), thrombocyte-lymphocyte ratio (PLR) and red blood distribution width (RDW) values at the moment of diagnosis. Material and Method: Patients (n=201) of gastric cancer who were recently diagnosed at Ondokuz Mayıs University, Faculty of Medicine, Medical Oncology clinic between the dates January 2006 and September 2014 and who were treated and followed up at our center were included in the study. They were divided into two groups as Group A (n=122) consisting of stage 1-2-3 patients and Group B (n=79) consisting of stage 4 patients. The relationship of survival between NLR, PLR and RDW and the groups was assessed with life analysis. For these parameters, cut-off values were found by using ROC analysis. Results: When the relationship between the parameters and the survival of the patients with gastric cancer was examined, it was statistically shown that with the increase in NLR, longevity significantly decreased and thus prognosis became worse (p<0.05). No significant relationship was found between PLR and RDW and the patients’ sruvival. Conclusion: There is a statistical relationship between NLR at the moment of diagnosis in gastric cancer and prognosis and survival. Rates of survival decrease as this rate increases and the prognosis becomes worse.

Keywords:

Gastric cancer, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width,

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