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The aims of the study to investigate the effects of perceived social support, stress management and socio-demographic variables on life satisfaction and general health status of mothers of children with an intellectual disability. The research was designed as a cross-sectional descriptive type. Mothers of 104 children with intellectual disability who were educated in Special Education and Rehabilitation Centers under the authority of Izmir Provincial Directorate of National Education constituted the sample of the study. The data were collected through the face-to-face interview method using the Satisfaction with Life Scale (SWLS), The General Health Questionnaire (GHQ), the Multidimensional Scale of Perceived Social Support (MSPSS), the Scale of Coping with Stress and the Sociodemographic Questionnaire. The data were evaluated with numbers (points), percentages, Independent samples t-test, Kruskall Wallis, Mann-Whitney U Test and Pearson correlation analysis. There was a negative relationship between the General Health Status and Life Satisfaction (p = 0.01). At the end of the study, it was found that social support affects the general health status and life satisfaction positively.