Eylem ÇAĞILTAY, Muhammed ALTINIŞIK, Sjaak POUWELS, Nur DEMİR, Fahrettin AKAY

PREDİYABETİK HASTALARDA YAPILAN ORAL GLİKOZ TOLERANS TESTİ ESNASINDA KOROİD KALINLIĞININ ÖLÇÜLMESİ: SPEKTRAL DOMAİN OPTİK KOHERENS TOMOGRAFİ ÇALIŞMASI

Amaç: Akut hiperglisemik değişikliklerin prediyabetli hastalarda koroidi nasıl etkilediğini araştırmak. Gereç ve Yöntem: Hastalara en az 8 saat kalori alınmaması sonrası 75 g oral glukoz tolerans testi (OGTT) uygulandı. Koroid kalınlığı (ChT), yeni nesil spektral domain optik koherens tomografi (SD-OCT) ile ölçüldü. Bulgular: Koroid kalınlığındaki değişiklikler gruplar arasında farklılık göstermiştir. Prediyabetli bireylerde, foveaya 500 µm mesafedeki subfoveal, nazal ve temporal lokasyonların yanı sıra ortalama ChT’de geçici bir artış gözlenmiştir. OGTT’nin ilk saatinde; prediyabetik grupta subfoveal koroid kalınlığı farkı 1,52±4,11 µm (aralık, -11,00/24,00 µm) iken, kontrol grubunda subfoveal ChT farkı -0,22±1,74 µm (aralık -2,00/8,00 µm) olarak ölçüldü. Sonuç: Akut hiperglisemik değişikliklerin anlık ölçümlerle saptanması, hastalığın oküler yapılar üzerindeki etkisini daha iyi anlamamıza yardımcı olabilir.

Anahtar Kelimeler:

Koroid kalınlığı, oral glukoz tolerans testi, spektral domain optik koherens tomografi

THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY

Objective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes. Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting. The measurement of choroidal thickness (ChT) was done with new generation spectral domain optical coherence tomography (SD-OCT). Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p

Keywords:

Choroidal thickness, oral glucose tolerance test, spectral domain optical coherence tomography,

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