Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Amaç: Bu çalışmada amacımız kronik venöz yetmezlik ve varis tedavisinde siyanoakrilat (CA) ile yapılan safen ven embolizasyonunda işleme bağlı ortalama trombosit hacminin (MPV) ve trombosit sayısının değişimini saptamak ve oluşabilecek venöz tromboembolizm olaylarına açıklık getirmektir.Materyal ve Metot: Bu çalışmaya dâhil edilen 60 hasta Adıyaman Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisine Polikliniğine başvuran varis ve kronik venöz yetersizliği olan hastalardan seçildi. CA ile safen ven embolizasyonu yapılan hastaların dosya taraması dijital ortamda yapılarak USG ve laboratuvar tetkikleri incelendi. İşlem yapılan toplam 437 hastadan işlem öncesi ve sonrası hemogram ve biyokimya tetkikleri alınan60hasta çalışmaya dahil edildi. Hastaların işlem öncesi ve sonrası trombosit sayısı ve ortalama trombosit hacmi değerlendirildi. Bulgular: Postoperatif(post-op) 1. Saat ve 1.ay MPV değeri preoperatif (pre-op) döneme göre anlamlı (p ˃ 0.05) değişim göstermezken post-op 3.gün MPV değeri pre-op döneme göre anlamlı (p ˂ 0.05) artış gösterdiği tespit edildi. Post-op 3.gün MPV değeri post op 1.saate göre anlamlı (p ˂ 0.05) artış ve post-op 1.ay MPV değeri post-op 3.güne göre anlamlı (p ˂ 0.05) düşüş göstermiştir.Sonuç: MPV işlemden 1 gün sonra normal değerlerden anlamlı artış göstermez iken post op 3. günde anlamlı artış gösterdi. MPV’ün artan trombojenite ile ilişkili olduğunu varsayarsak varis tedavisinde kullanılan minimal invaziv yöntemlerden olan CA ile safen ven embolizasyonu post-op erken (İlk bir hafta içinde) dönemde tromboembolik olaylara sebep olabilmektedir.

Anahtar Kelimeler:

Mean platelet volüm, Varis, Siyanoakrilat, Tromboembolizm

The Change Of Average Platelet Volume and Platelets Count in Saphenous Vein Embolization Using By Cyanoakrilate

Background: In the present study, it is aimed to determine the intervention-related change in the mean platelet volume (MPV) and platelet count in saphenous vein embolization performed using cyanoacrylate in chronic venous stasis and varicose treatment, as well as explaining the possible venous thromboembolism events.Methods: 60 patients involved in the present study were selected from the patients, who had varicose and chronic venous stasis and who applied to the Cardiovascular Surgery Polyclinic of Medical Faculty of Adıyaman University. The files of patients undergone saphenous vein embolization using CA were performed digitally and their USG and laboratory results were analyzed. Among 437 patients, 60 patients’ undergone hemogram and biochemical examination before and after the intervention were involved in the present study. The preoperative (pre-op) and postoperative (post-op) platelet counts and mean platelet volumes of the patients were analyzed. Results: When compared to the pre-op period, no significant change was observed on 1st post-ophour and 1stpost-op month (p ˃ 0.05), however the MPV value observed on the 3rd post-op day was significantly higher than the pre-op period (p ˂ 0.05). The MPV value observed on the 3rd post-op day was statistically higher than on 1st post-op hour (p ˂ 0.05) and the MPV value observed on the 1st post-op month was statistically significantly lower than on 3rd post-op day (p ˂ 0.05). Conclusion: MPV did not significantly increase from the normal values on the 1st postoperative day, whereas it significantly increased on the 3rd postoperative day. Assuming that MPV is related with the increasing thrombogenicity, it can be stated that the saphenous vein embolization by using CA that is one of the minimally invasive methods used in varicose treatment may cause thromboembolic events in the early pre-op period (in the first week).

Keywords:

Mean platelet volume, Varicose, Cyanoacrylate, Thromboembolism,

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