Yavuz YEŞİLOVA, Enver TURAN, Emin ŞAVİK, Hatice SEZEN

Sistemik isotretinoin tedavisi alan orta ve şiddetli form akne vulgarisli hastalarda hematolojik parametrelerin değerlendirilmesi

Amaç: İsotretinoin ISO orta ve şiddetli form akne vulgaris tedavisinde yaygın olarak kullanılan bir oral aktif retinoik asit derivesidir. Bu çalışmada oral ISO tedavisi başlanan orta ve şiddetli form akne vulgarisli hastalarda hematolojik parametrelerin retrospektif olarak değerlendirilmesi amaçlanmıştır. Metod: Çalışmaya dermatoloji polikliniğine başvuran ve klinik olarak akne vulgaris tanısı konularak oral isotretinoin tedavisi başlanan 50 hasta alındı. Hastaların tedavi öncesi ve tedavi başlangıcından üç ay sonrasındaki hematolojik parametreleri [hemoglobin Hgb , hematokrit Htc , trobmosit Plt , ortalama platelet hacmi MPV ve lökosit WBC ] retrospektif olarak incelendi.Bulgular: Hastaların tedavi öncesi ve sonrası değerleri karşılaştırıldığında tedavi sonrası trombosit değerlerinin tedavi öncesine oranla yükseldiği, buna karşılık ortalama platelet hacminin düştüğü görüldü p0.05 . Sonuç: ISO tedavisi alan hastalarda ortalama platelet haci düşerken, platelet sayısı artmaktadır. Bu değişiklik fizyolojik sınırlar içinde omakla birlikte ISO tedavisi alan hastalar bu açıdan periyodik olarak takip edilmelidir

Anahtar Kelimeler:

Akne vulgaris, isotretinoin, trombosit sayısı, ortalama platelet hacmi

Assessment of haematological parameters in moderate to severe form acne vulgaris patients treated with systemic isotretinoin

Background: Isotretinoin ISO is a new orally active retinoic acid derivative commonly used for the treatment of moderate and severe forms of acne vulgaris. In this study, treatment was started orally ISO in patients with moderate and severe forms of acne vulgaris aimed to evaluate hematological parameters retrospectively.Methods: 50 patients were enrolled who admitted to the dermatology clinic and clinically diagnosed with acne vulgaris and oral isotretinoin treatment was started. Hematological parameters before treatment and three months after onset of treatment of the patients [hemoglobin Hgb , hematocrit Hct , platelet count PLT , mean platelet volume MPV and leukocyte WBC ] were analyzed retrospectively.Results: Compared to values of patients before and after treatment, after treatment platelet values has risen compared to pre-treatment, in turn, showed a decrease of mean platelet volume p 0.05 .Conclusion: ISO-treated patients mean platelet volume decreases, while the platelet count is increasing. Although these changes within the physiological limits that ISO-treated patients should be monitored periodically by these terms

Keywords:

Acne vulgaris, isotretinoin, platelet count, mean platelet volume,

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