Primer Anorektal Malign Melanom: 5 Yıllık Tek Merkez Deneyimi Türkçe

Amaç: Gastrointestinal sistemde Malign Melanom beklenmedik bir durumdur fakat nadir değildir. Primer Malign melanom anorektol bölgede nadir görülür. Uzun dönem yaşam beklentisi nadirdir. Çoğu hasta tedavi edilemeyen sistemik hastalık nedeniyle kaybedilmektedir. Bu çalışmada Malign Melanomla ilgili klinik deneyimlerimizi aktararak, tanı ve tedavisi ile ilgili güncel literatür bilgilerini paylaşmayı amaçladık.Materyal ve metot: 2006-2011 tarihleri arasında cerrahi girişimde bulunulan ve patolojik tanısı Malign Melanom olan 10 olgu retrospektif olarak incelendi. Hastalar yaş, cinsiyet, klin görünüm, metastaz varlığı, immünhistokimyasal özelliği, takip süreleri ve uygulanan cerrahi girişimin açısından değerlendirildi.Bulgular: Hastaların 4'ü kadın, 6'si erkek olup yaş ortalaması 67,7 ' idi. Beş hastada cerrahi tedavi ile kür sağlandı. Dört hasta inoperable olarak tespit edildi. Tüm vakalarda S-100 pozitifti. Hastalar ortalama 15 ay takip edildi. Sonuçlar: Primer anorektal malign melanom, anorektal tümörlerin ayırıcı tanısında nadir bir nedendir. Tercih edilen tedavi seçeneği cerrahidir. Palyatif amaçlı kemoterapi ve immünoterapi kullanılır. Tedavi yöntemlerindeki gelişmelere rağmen, bu tümörün prognozu halen kötüdür

Primary Anorectal malignant melanoma: Five years of experience at a single center

Background: Malignant melanoma in the gastrointestinal tract is uncommon but not rare. Primary malignant melanoma is a rare entity in the anorectum. Long–term survival is rare, as most patients die of disseminated systemic disease regardless of treatment. In this study we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about malignant melanoma.Methods: The 10 patients who was operated and pathologic examination were reported as malignant melanoma between 2006–2011 years have been viewed retrospectively. Patients' age, sex, clinical, presence of metastasis, survival and immunohistopathologic features and treatment methods were evaluated.Results: Four of patients were women and 6 of them were men whose age averages were 67,7 . With a surgical intervention 5 of them had been cured. 4 cases accepted as an inoperable. S-100 was positive in our all cases. Patients had been observed for 15 months.Conclusions: Primary anorectal malignant melanoma is a rare cause in the differential diagnosis of anorectal tumors. Surgery remains the therapy of choice. Chemotherapy and immunotherapy are principally used in a palliative setting. Despite advances in therapy, the prognosis of this tumor entity remains unfavorable

Kaynakça

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