Düşük Serum Serulapozmin Aktivitesi Aterosklerozun Göstergesi Olabilir: Kesitsel Bir Çalışma

Giriş Daha önceki çalışmalarda serum seruloplazmin (Cp) seviyesi ile aterosklerotik kalp hastalığı arasında ilişki bulunmuş ancak bu ilişkinin iskemi mi yoksa ateroskleroz mu kaynaklı olduğu araştırılmamıştır. Bu çalışmanın amacı Cp aktivitesinin koroner ateroskleroz ve iskemi ile ilişkisini ayrı ayrı değerlendirerek hangisine bağlı olduğunu araştırmaktır. Materyal ve Metod Koroner anjiyografi için alınan 90 hasta çalışmaya dâhil edildi. Hastalar koroner arter hastalığı (KAH): En az 1 ana koroner arterinde % 70 ve üzerinde darlık olan ve iskemi varlığı kanıtlanmış hastalar; nonkritik koroner darlık (NOK): en az 1 ana koroner arterinde % 70'in altında darlığı olan ve açık iskemisi olmayan, normal koroner arter (NKA): koronerlerinde herhangi bir aterosklerotik hastalık tespit edilemeyen ardışık 30 hasta şeklinde gruplandı. Çalışmaya alınan tüm hastalardan enzimatik olarak ticari kitlerle lipid profili ve Erel Metodu serum Cp aktivitesi ile ölçüldü. Sonuçlar Gruplar yaş cinsiyet, beden-kitle indeksi ve lipit profili yönünden benzerdi (p>0,05). Serum Cp aktivitesi 3 grup arasında anlamlı düzeyde farklı idi (p<0,05) ve hasta gruplarında NKA grubuna göre düşüktü. Alt grup analizinde bu farkın NKA grubuyla diğer gruplar arasında olduğu görüldü. Pearson korelasyon analizinde serum Cp aktivitesi ile total kolesterol ve düşük dansiteli lipoprotein kolesterol ile negatif ve yüksek dansiteli lipoprotein kolesterol ile pozitif ilişkili olduğu görüldü. Linier regresyon analizinde bu parametrelerden serum Cp aktivitesini sadece serum yüksek dansiteli lipoprotein kolesterol seviyesinin etkilediği görüldü.Tartışma Sonuç olarak, koroner ateroskleroz olan hastalarda serum Cp aktivitesi yüksek oksidatif stresi gösterecek şekilde düşük olarak ölçüldü. İskemi olması ya da olmamasının sonucu etkilemediği gözlendi.

Anahtar Kelimeler:

Seruloplazmin, Ateroskleroz, Oksidatif Stres

Low Serum Ceruloplasmin Activity May Be An Indicator Of Atherosclerosis: A Cross Sectional Study

Background In previous studies, serum ceruloplasmin (Cp) level have been shown to be correlated with atherosclerotic heart disease. But it has not been investigated which result from ischemia or atherosclerosis. The aim of this study, serum Cp activity assess in coronary atherosclerosis and ischemia and investigate to which it is connected. Methods 90 patients taken for coronary angiography were included in the study. Patients divided three groups such as coronary artery disease (CAD): at least one main coronary artery stenosis exceeding 70% and patients with proven ischemia presence; noncritical coronary artery stenosis (NOC): at least one main coronary artery stenosis less than 70% and no obvious ischemia, normal coronary artery (NKA): 30 consecutive patients with normal coronary artery. Lipid profiles of all patients were measured. And serum Cp activity was measured by Erel's method. Results Tree groups were similar in terms of age, gender, BMI and lipid profile (p> 0.05). Serum Cp activity was significantly different among groups (p <0.05). CP activity was significantly lower in the patient group compared to the NOC group. In the subgroup analysis this difference was observed among NKA group and other groups. Pearson correlation analysis showed that serum Cp activity is the negative with total cholesterol and low density lipoprotein cholesterol, positively correlated with high density lipoprotein cholesterol (HDLK). Linier regression analysis showed that only HDLK effect serum Cp activity from these parameters independently. Conclusions As a result, in patients with atherosclerosis, serum Cp activity was lower than in patients with normal coronary arteries. The presence of ischemia did not affect the result.

Keywords:

Ceruloplasmin, Atherosclerosis, Oxidative Stress,

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