Drugs abuse and trafficking pose serious threats to safety, security and productivity of societies. Many social and economic factors raise market demands for drugs abuse that is escalated more by the cheap available means of transportation. Equally important, the Internet and other means of communications could widen global drugs demand’ and trafficking. It is also connected to other international organized crimes that need to be campaigned against, not only by us as police leaders but also as governments, regional and international organizations, as well as civil society sectors. Such integrated regional and international co-operation and support is very essential for combating this serious crime. In some particular regions, this crime destabilizes governments due to its association to rebel’s activities, money laundering and corruption. This paper aims to highlight part of the international cooperation in combating drugs abuse and trafficking. Focus has been put on the Eastern African region cooperation in fighting cross-border and international organized crimes like drug trafficking. More emphasis would be extended to Sudan for Narcotics and Drugs combating program, as one of the areas which Sudan is focusing and closely collaborating with foreign counterparts. In the first place, the joint work of the United Nation Office for Drug and Crime UNODC with Sudan to become a Regional Drug Centre is illustrated. Furthermore, Sudan also has-been chosen as a Regional Centre of Excellence for Forensic Sciences including drug detection, as well as being adopted by the INTERPOL as a Training Centre for Drugs K9 at the region. In addition,capacity building which forms an important component and an integral part in cooperation efforts will be presented briefly