19. yiizyt!da Osma11/1 iilkesi11de bin;ok Hristiya11 111isyo11 er grubu faaliyette b11!111111111filur. 81111/ar ir;: inde en akt(( o/an/ar da Amerikan Protesta11 111i.1yo11 erlcridir. Otke11i11 deiJi~ ik yerlcrinde e~·k il ettikleri kilise, okul ve saire gibi k11ru111/ar aract!1g1yla faaliyetleri11i siirdiire11 A111 erika/1 111is:vo11 erleri11 Anadolu 'daser;:tikleri 611 e111/i 111 erkezlerdc11 biri de Antep /iri o/11111 ~· 111r. A11tep 'i b6/gesi11i11 111isyo11 111 erkezi '1ali11 e getirerek, burada birr;:ok k11ru111 ar;:a11 Amerikalt!ar111:jeliirdeki en 611e111/i nliiesseseleri A11tep Amerika11 Koleji 'ydi. Kole) 1876 yt!111daac,:t/1111~· ve a{:t!1~·11ula11 itibare11 de her za111a11 fie /iirdeki Er111e11i '1 areketlerini11ir;:erisinde yer a/1111,~11r. Biri11ci Dfinya Savafj t so11ras1 ba~-layan ~ga ll r s1ras111dada ~·ga i giir;:leri11 karargt1'1 olarak k11lla11d1k/ar1 ko/ej. Milli Miicade/eni11ard1nda11, 1924 yt!mda, Antep 'ten 1-fa/ep 'e 1a~· u11111 ltr . 

Throughout the 19'" ce11!U1J' many Christian 111issio11a1:i1 groups perfor111ed activities i11 the Ottoman land, fiwn which the most active ones were the American Protestant missionaries. One of the most important bases that the American missionaries who carried on their activities with the i11sfifufio11s such as ch11rches, schools etc., they had co11sfr11 cted 011 the diverse parts of the cou11!1 J1, chose in the A 11 atolia was A i11tab. The most i111porta11t i11 stit11tio11 of the Americans who established many frn111datio11 s after having appointed Ai11tab as their 111issio11 center, was the A111erica11 College of Ai11tab. Th e college wasfo1111ded i11 1876 and it was ahvays i11 volved i11 the Ar111 e11ia11 111ove111ents since then. The college which was used as a headquarters by the occupying fo rces during the invasions, broke out a.fier World War!, was 111ovedfi·o111 Aintab to 1-!alep in 1924 after The Turkish National Struggle.