LAKTİK ASİT BAKTERİLERİNİN AFLATOKSİN B1 BAĞLAYICI VE ANTİKANSEROJEN ÖZELLİKLERİ

Laktik asit bakterileri starter kültür olarak gıda endüstrisinde yaygın olarak kullanılan, insan mikrobiyotasının doğal üyeleridir. Son yıllarda laktik asit bakterileri üzerine yapılan araştırmalar mikotoksinleri, özellikle de aflatoksin B1’i (AFB1) biyolojik etkisizleştirme özellikleri üzerinde yoğunlaşmaktadır. Elde edilen sonuçlar AFB1’in ve metaboliti olan AFM1’in bağlama özelliklerinin türler hatta suşlar arası farklılık gösterebildiğini ortaya koymaktadır. Bu nedenle yapılan çalışmalar genellikle üstün potansiyeli olan suşları tespit etmeyi amaçlamaktadır. Laktik asit bakterileri AFB1 ve AFM1 gibi genotoksinleri ortamdan uzaklaştırarak DNA-biyokoruyucu özellik göstermekte, dolayısı ile konakçı sağlığının devamlılığına katkı sağlamaktadır. Ayrıca yapılan in-vitro çalışmalarda laktik asit bakterilerinin kanser hücrelerine karşı anti-proliferatif etki göstererek, çoğalmalarını önlediği de ifade edilmektedir. Bu derlemede laktik asit bakterilerinin gıda matriksi ve besiyerinde AFB1 ve AFM1’i uzaklaştırma özelliklerinin mekanizması ayrıntılı olarak ele alınmış,  ayrıca anti-kanserojen etkileri üzerine yapılan son çalışmalar hakkında bilgi verilmiştir.

AFLATOXIN B1 BINDING AND ANTI-CARCINOGENIC PROPERTIES OF LACTIC ACID BACTERIA

Lactic acid bacteria that are used as starter cultures in food industry are natural members of human microbiota. In recent years, researches are focused on lactic acid bacteria’s mycotoxin especially aflatoxin B1 (AFB1) biological detoxification features. The results obtained showed that AFB1 and its metabolite AFM1binding property may change between even the strains are revealed. So studies are aimed to find the superior strain. Lactic acid bacteria show anti-genotoxic properties due to removal genotoxins such as AFB1 and AFM1 thus help to maintain host health. Also in vitro studies are reported that lactic acid bacteria showed anti-proliferative effect and avoid the growth of cancer cells. In this review, it is aimed to combine the removal mechanism of AFB1 and AFM1 from food matrix and medium by lactic acid bacteria extensively and give the current information about the anti-carcinogenic effect studies. 

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