Mustafa Ümit ÜNAL, Aysun ŞENER, Kardelen CEMEK

BİYOAKTİF PEPTİTLERİN SAĞLIK ÜZERİNE ETKİLERİ

Biyoaktif peptitler aminoasitlerin peptit bağlarıyla bağlanması sonucu oluşan, vücut fonksiyonlarına olumlu etkisi olan ve sağlığı etkileyebilen spesifik protein parçalarıdır. Bazı biyoaktif peptitler doğal kaynaklarında serbest olarak bulunurlar. Ancak, bilinen biyoaktif peptitlerin büyük çoğunluğu ana proteinlerin yapısı içerisinde inaktif halde bulunurlar ve proteolitik enzimlerle hidroliz veya fermantasyon sonucu serbest kalırlar. Biyoaktif peptitler, sindirim, endokrin, kardiyovasküler, bağışıklık ve sinir sistemini ve dolayısıyla insan sağlığını etkilerler. In vitro ve in vivo çalışmalarda antimikrobiyal, antitrombotik, antihipertansif, opioid, immünomodülatör, kolesterol düşürücü, mineral bağlayıcı ve antioksidatif özellikler gösterdikleri ortaya konmuştur. Bu derlemede biyoaktif peptitlerin tanımlanması, kaynakları, biyoaktif özellikleri ve sağlık üzerine etkileri ele alınmıştır.

Anahtar Kelimeler:

Proteinler, Peptitler, Biyoaktivite, Biyoaktif Peptit Kaynakları, Sağlık

EFFECTS OF BIOACTIVE PEPTIDES ON HEALTH

Bioactive peptides are formed by amino acids joined by peptide bonds and defined as specific protein fragments that have a positive impact on body functions, and may influence health. Some bioactive peptides exist free in its natural source. However, the vast majority of known bioactive peptides are inactive within the structure of the parent proteins and are released by enzymic hydrolysis or fermentation. Bioactive peptides play a significant role in human health by affecting the digestive, endocrine, cardiovascular, immune, and nervous systems. In vitro and in vivo studies showed that bioactive peptides exhibited antimicrobial, antithrombotic, antihypertensive, opioid, immunomodulator, cholesterol lowering, mineral binding and antioxidant roperties. In this review, identification, sources, bioactive properties and health effects of bioactive peptides are addressed.

Keywords:

Proteins, Peptides, Bioactivity, Bioactive Peptide Sources, Health,

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