Sigaranın Romatoid Artrit Üzerine Etkileri

Amaç:RomatoidArtrite sebep olan faktörlerden biri olan ve hastalığın seyrini ve sero-pozitivitesini etkileyen sigara kullanımının Romatoidartrit gelişimi üzerine etkilerinin incelenmesi. Materyal ve Metod: 15 08. 2009 - 15. 06. 2010 tarihleri arasında Süleymaniye Eğitim Hastanesine başvuran, Amerikan Romatoloji Kurulunun teşhis kriterlerine gore seçilen 73 kadın (%79) ve 19 erkek (%21) toplam 92 romatoit artritli olgu çalışmaya alınmıştırr. Sigara kullanan hastaların detaylı öyküleri alınarak, hastalıkgelişimi DAS28J"e (eklemlerde hastalık gelişim değeri 28) göre irdelenmiştir. Bulgular:Sigara kullanan 46 hastada ilerleyen bir romatoid artit olduğu ve 38 hastada (%82.6) DAS28J"ye göre değerlendirildiğinde, hastalığın seyrinin oldukça ilerlemiş olduğu tesbit edildi (p:0.04). 42 (%91.3) Sigara kullanımı ve seropozitivite arasında da pozitif bir ilişki olduğu belirlendi (p:0.000). Sonuç: DAS28J verilerine gore değerlendirilme yapıldığında, sigara kullananların büyük bir kısmında hastalığın ilerlemiş olduğu görüldü. Seropozitif ve sigara arasında pozitif bir ilişki bulundu.

Anahtar Kelimeler:

Sigara kullanımı, hastalıkaktivitesi, RF, romatoid artrit.

The Effect of Cigarette Smoking on Rheumatoid Arthritis.

Purpose: To investigate the effect of smoking on rheumatoid arthritis as a causative factor, sero -positivity and activity. Materials and Methods: This case control study which is carried out in the rheumatology division of Suliamaniya teaching hospital & clinic from 15th August 2009 to 15th June 2010, Ninety_ two patients 73(79%) females and 19(21%) males who fulfilled the American College of Rheumatology diagnostic criteria for diagnosis of adult rheumatoid arthritis were included compared to 92 controls. Detail history of smoking taken and disease activity assessed according to DAS28j(Disease activity score of 28 joints). Results: All forty six smoker patients had active disease , 38(82.6%) had highly active disease according to DAS28j,these results are statistically significant (P-value =0.04), and 42(91.3%) of them had rheumatoid factor which means the positive relation between smoking and seropositivity also (P-value =0.000). Conclusion: Majority of smokers demonstrated highly active disease according to DAS28j measurement for disease activity , and the relation of smoking with seropositivity found to be positive.

Keywords:

Smoking , activity, RF, rheumatoid arthritis.,

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YazışmaAdresi / Address for Correspondence: Dr.Raouf Rahim Mirza Sulaimaniya University Faculty of Medicine IRAQ E-mail: raofmerza@yahoo.com. G eliştarihi/Received on :03.04.2014
Kabul tarihi/Accepted on: 09.04.2014