Obez Hastalarda Diz Osteoartrit Şiddetinin Göstergesi Olarak Sinoviyal Sıvıda Adinopektin ve Leptin Konsantrasyonu

Amaç: Osteoartrit (OA), eklem kıkırdak kaybı,osteofit oluşumu ve kıkırdak altındaki kemikte meydana gelen değişimlerle karakterize edilen, oynar eklemin kronik dejeneratif eklem hastalığıdır. Vücut ağırlığının artması, diz eklemlerini biyokimyasal olarak etkiler, adiponektin ve leptin gibi adipokinlerin konsantrasyonunu değiştirir. Bu çalışmada obez hastalarda, adiponektin ve leptin sinoviyal sıvı konsantrasyonu ile diz osteoartrit şiddeti arasında korelasyon saptanmıştır. Materyal ve Metod: Çalışmaya 45 hasta dahil edilmiştir. Sinoviyal sıvıda adiponektin ve leptin konsantrasyonlarının saptanmasında ELISA kullanılmıştır. Diz OA’sının şiddeti Kellgren-Lawrence derecelendirmesi ile yapılmıştır. Data analizleri SPSS ile yapılmıştır. Bulgular: Leptin ölçümlerine göre, leptin konsantrasyonları diz OA’sının şiddeti ile pozitif korelasyon göstermektedir. Bunun aksine adiponektin konsantrasyonları negatif korelasyon göstermektedir. Sonuç: Bu çalışma, OA’nın şiddeti ile sinovial sıvıdaki adiponektin ve leptin konsantrasyonları arasında bir ilişki olduğundan, adiponektin ve leptinin biomarker fonksiyonuna sahip olduğunu desteklemektedir. Sonuçlar aynı zamanda leptin ve adiponektinin OA üzerinde fonksiyonu olduğunu göstermektedir

Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients

Purpose: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. An increase of weight bearing affect on knee joint biomechanically and alter concentration of adipokines, such as adiponectin and leptin. Herein we reported a correlation between adiponectin and leptin synovial fluid concentration with the severity of knee OA in obese patients. Material and Methods: Totally 45 patients were included in this research. ELISA was used to determine adiponectin and leptin concentrations of synovial fluid. The severity of knee OA was classified by Kellgren-Lawrence grading scale. Data analysis was conducted using SPSS for windows. Results: Based on the leptin measurement, it was shown that leptin concentrations were correlated positively with the severity of knee OA. Vice versa, adiponectin concentrations were correlated negative. Conclusion: Our study was support the biomarker function of adiponectin and leptin concentration on synovial fluids, in which those concentrations were related with the severity of OA. Those results also suggested the function of leptin and adiponectin on OA.

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  • Berenbaum F. Osteoarthritis, Pathology and pathogenesis. In: Klippel JH, Stone JH, Crofford LC, White PH, editors. Primer on the Rheumatic Diseases. 3th ed. New York: Springer Science+Business Media, LLC; 2008:224-40.
  • Cesare PD, Abramson SB. Pathogenesis of osteoarthritis. In: Harris ED, Budd RC, Genovese MC, Rheumatology. 7th ed. Elsevier Saunders, 2005.
  • Lementowski PW, Zelicof SB. Obesity and osteoarthritis. Am. J. Orthop. 2008;37:148-51.
  • Franklin JA. Osteoarthritis, Epidemiologic and genetic aspects. Lund University, Faculty of Medicine Doctoral Dissertation Series, Sweden 2010;71.
  • The National Collaborating Centre For Chronic Conditions. Osteoarthritis: National Clinical Guideline for care and management in adults. Royal College of Physicians of London 2008:3-10.
  • Trayhurn P, Wood IS. Horizons in Nutritional Science: Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 2004;92:347- 55.
  • Yusuf E, Facsinay AI, Bijsterbosch J, Wieringa IK, Kwekkeboom J, Slagboom E, et al. Association between leptin, adiponectin and resistin and long- term progression of hand osteoarthritis. Ann. Rheum. Dis. 2011;70:1282–4.
  • Scotece M, Conde J, Gómez R, López V, Lago F, Reino JJG, et al. Beyond Fat Mass: Exploring the role of adipokines in rheumatic diseases. Sci. World J. 2011;11:1932-47.
  • Hafera, Najirman, Manaf A, Azmi S. Produk degradasi kolagen tipe II: hubungannya dengan derajat klinis pada osteoartritis. Dalam: Setiyohadi B, Kasjmir YI. Editor. Temu Ilmiah Reumatologi. Jakarta, 2010:138-42.
  • Felson DT. Osteoarthritis. In: Fauci AS. Editor. Harrison’s Rheumatology. 2sd ed. The McGraw-Hill Companies, Inc. 2010:223-34.
  • Sower MR, Carrie A. The evolving role of obesity in knee osteoarthritis. Curr. Opin. Rheumatol. 2010;22:533-7.
  • Isa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol. Aging Age Relat. Dis. 2012;2:1-7.
  • Conde J, Scotece M, Gomez R, Lopez V, Reino JG, Gualillo O. Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis. 2011:1-9.
  • Plebanczyk M, Janicka I, Musialowicz U, Burakowski T, Maslinski W. Adipose tissues from rheumatoid arthritis and osteoarthritis patients differ in cytokine and adipokine production. Ann. Rheum. Dis. 2011;70:91–4.
  • Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis. Res. Ther. 2011;13:1-11.
  • Sowers MR, Gutierrez CA. The evolving role of obesity in knee osteoarthritis. National Institute of Health Public Access Author Manuscript March 2012:1-8.
  • Yusuf E. Metabolic factors in osteoarthritis: obese people do not walk on their hands. Arthritis Res. Ther. 2012;14:1-2.
  • Gómez R, Conde J, Scotece M, Reino JG, Lago F, Gualillo O. What’s new in our understanding of the role of adipokines in rheumatic diseases? Nat. Rev. Rheumatol. 2011;7:528-36.
  • Ku JH, Lee CK, Joo BS, et al. Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin. Rheumatol. 2009;28:1431-5.
  • Gutierrez CAK. Knee osteoarthritis: intersections of obesity, inflammation, and metabolic dysfunction. [dissertation]. The University of Michigan; 2012.
  • Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El-Hachem K, et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP- 13 regulation in osteoarthritis. Eur. Cell. Mater. 2011;21:202-20.
  • Orita S, Koshi T, Mitsuka T, Miyagi M, Inoue G, Arai G, et al. Associations between proinflamatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet. Disord. 2011;12:1-8.
  • Fincham BM, Jones D. Articular Cartilage Degeneration Etiologic Association with Obesity. Emerging Issues in Medical Diagnosis and Treatment Issue 2013;1:1-8.
  • Conde J, Scotece M, G´omez R, Lopez V, Reino JJG, Gualillo O. Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis. 2011:1-8.
  • Guiterrez CA. Knee osteoarhtritis: intersection of obesity, inflammation, and metabolic dysfunction. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Epidemiologic Science) in The University of Michigan 2012.
  • Berry PA, Jones SW, Cicuttini FM, Wluka AE, Maciewicz RA. Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis. Rheum. 2011;63:700-7.
  • Hassanali SH. Osteoarthritis: A look at pathophysiology and approach to new treatments: A Review. East. Afr. Orthop. 2011;5:51-7.
  • Heijink A, Gomoll AH, Madry H, Drobnic M, Filardo G, Mendes JE, et al. Knee: Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee. Surg. Sports Traumatol. Arthrosc. 2012;20:423–35.
  • Dahlberg L. Cartilage quality, overweight and osteoarthritis: a case for new behavior. Ann. Rheum. Dis. 2012;71:1-3.
  • Henrotin Y. Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives. Osteoarthr. Cartilage. 2012;20:215-7.
  • Rosengren S, Firestein GS, Boyle DL. Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay. Clin. Vaccine. Immunol. 2003;10:1002-10.
  • Catterall JB, Stabler TV, Flannery CR, Kraus VB. Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res. Ther. 2010;12:1-9.
  • Blüher M. Obesity and metabolic syndrome: clinical relevance of adipokines. Diabetes. Metab. J. 2012;36:317-27.
  • Massengale M, Lu B, Pan JJ, Katz1 JN, Solomon DH. Adipokine hormones and hand osteoarthritis: radiographic severity and pain. PloS One. 2012;7:1- 5.
  • Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F. Obesity and osteoarthritis: more complex than predicted Ann. Rheum. Dis. 2006;65:1403-5.
  • Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol. Aging Age Relat. Dis. 2012;2:1-7.
  • Yeon AL, Hyun MC, Sang HL, Hyung IY, Myung CY, Seung JH, et al. Synergy between adiponectin and interleukin-1β on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes. Exp. Mol. Med. 2012;44:440-7.
  • Tsu-Hsin C, Chen L, Ming-Shium H, Chih-Peng C, Der-Tsay C, Shu-Huei T. Evidence for a protective role for adiponectin in osteoarthritis. Biochim. Biophys. Acta. 2006;1762:711–8.
  • Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis Osteoarthr. Cartilage. 2013;21:16-21.
  • Korkmaz C. Response to ‘adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways’. Arthritis. Res. Ther. 2012;14:402.
  • Bay-Jensen AC, Slagboom E, Chen-An P, 45. Schmidt J. Relationship between serum and synovial Alexandersen P, Qvist P, et al. Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause: J. North. Am. Menop. Soc. 2012;20:578- 86.
  • Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, et al. Adiponectin as a biomarker of the metabolic syndrome. Circ. J. 2004;68:975-81.
  • Presle N, P. Pottie P, Dumond H, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis, contribution of joint tissues to their articular production. PharmD. Osteoarthr. Cartilage. 2006;14:690-5.
  • Ouellette A, Makowski AL. Sexual dismorphism and osteoarhtritis: The role of leptin. AAOS Now. 2010. fluid concentration of estradiol, leptin and the degree of osteoarthritis [thesis]. The Florida State University College of Human sciences. 2010.
  • Joffin N, Niang F, Forest AC, Jaubert AM. Is there NO help for leptin? Biochimie. 2012;94:2104-10.
Cukurova Medical Journal-Cover
  • ISSN: 2602-3032
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1976
  • Yayıncı: Çukurova Üniversitesi Tıp Fakültesi
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