Hacer YILDIZDAŞ, Dinçer YILDIZDAŞ, Ferda ÖZLÜ, Kurthan MERT, Neslihan MUNGAN

Hiperamonemili Üç Yenidoğan Bebekte Devamlı Venovenöz Hemodiafiltrasyon

Yenidoğan bebeklerde hiperamonemi, hipotoni, letarji, nöbetler ve koma ile karakterize ensefalopati tablosuna yol açabilir. Akut dekompanse olmuş hiperamonemi tedavisinde devamlı venovenöz hemodiafiltrasyon tedavi seçeneği olabilir. Burada hipotoni, konvülziyon ve hiperamonemi olan üç yenidoğan olgusu sunulmuştur.yaşamlarının ilk üç gününde amonyak değerleri 4609, 1023, 1949 microgram/ml idi. Devamlı venovenöz hemodiafiltrasyon ile başarılı bir şekilde tedavi edilerek tedavinin ilk 24 saatinde amonyak değerleri 268, 164 65 microgram/ml'ye azaltıldı.hafif hipotermi ve anemi komplikasyon olarak saptandı.

Anahtar Kelimeler:

Hemodiafiltrasyon, Yenidoğan, Hiperamonemi

Continuous Venovenous Hemodiafiltration in Three Newborn Patients with Hyperammonemia

In newborns, hyperammonemia leads to encephalopathy which is usually characterized by vomiting, hypotonia, lethargy, seizures and coma. Continuous venovenous hemodiafiltration (CVVHDF) is a modality choice to treat acute decompensation in hyperammonemia. Here we report three newborn patients with hypotonia, convulsion and hyperammonaemia. In the first three days of life, their serum ammonia levels were 4609, 1023 and 1949 µg/ml. They were successfully treated with CVVHDF and serum ammonia levels subsequently decreased to 268, 164 and 65 µg/ml in the first 24 hours of treatment. The complications were mild hypothermia and anemia.

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