Mustafa ULUBAY, Fahri Burçin FIRATLIGİL, Mustafa ÖZTÜRK, Özlem ÖZTÜRK, , Uğur KESKİN, Ulaş FİDAN, Hüseyin PEHLİVAN, Müfit Cemal YENEN

Hafif preeklampside üriner N-asetil-β-D-glukozaminidaz (NAG) ve renal tübüler hasar

Amaç: Bu çalışmada, normotansif gebe (kontrol) grubu ile hafif preeklampsi (çalışma) gruplarında 24 saatlik idrardaki N-asetil- β-D-glukozaminidaz seviyelerinin karşılaştırılması ve hafif preeklampsi hastalarında renal tubüler hasarın saptanması amaçlandı. Gereç ve Yöntem: Bu çalışma, 13 hasta çalışma grubunda ve 15 hasta kontrol grubunda olmak üzere planlandı. 24 saatlik idrar çıkışları ve 24 saatlik idrarda protein, glomerüler filtrasyon hızı, sistolik ve diyastolik arter basınçları, serum kreatinin ve 24 saatlik idrarda NAG değerleri hesaplandı.Bulgular: Çalışma ve kontrol gruplarında, 24 idrar volume (mL), serum kreatinin (mg/dL) ve glomerüler filtrasyon hızında istatistiksel olarak fark saptanmamıştır. Gruplar arasında, 24 saatlik idrarda protein (U/l), sistolik ve diyastolik arter basınçları (mmHg) ve 24 ssatlik idrarda NAG değerleri istatistiksel olarak anlamlı bulundu. NAG ve 24 saatlik idrarda protein değerleri arasında anlamlı korelasyon bulundu.Sonuç: Bu çalışmada; hem glomerüler, hem de renal tubüler hasarı gösteren NAG ile birlikte protein değerlendirilmesinin etkisi önemlidir, ve hafif preeklampsi hastalarında renal tubüler hasar oluşurken serum kreatinin seviyelerinde değişikliğe sebep olmadığını bulunmuştur.

Anahtar Kelimeler:

N-asetil-β-D-glukozsaminidaz, hafif preeklampsi, proteinüri

Urinary N-acetyl-β-D-glucosaminidase (NAG) and renal tubular injury in mild preeclampsia

Purpose: This study aimed to evaluate the amount of N-acetyl-β-D-glucosaminidase (NAG) in the 24 h urine output of patients with normotensive pregnancies (control) group with mild preeclampsia (study) group and to detect the presence of renal tubular injury in mild preeclampsia patients. Material and Methods: The study was conducted among 13 patients study group and 15 patients control group. The 24 h urine output and protein, glomerular filtration rate, systolic and diastolic arterial pressures, serum creatinine, and 24 h urine NAG values of the pregnants were calculated. Results: Statistical difference was not detected among gestational week, 24 h urine volume (mL), serum creatinine (mg/dL), and glomerular filtration rates of the control and the study groups. The differences of the 24 h urine protein (U/l), systolic and diastolic arterial blood pressures (mmHg), and 24 h urine NAG between groups were statistically significant. A significant correlation was found between the NAG values and 24 h urine protein.Conclusion: This study shows that; evaluating the impact of protein assessment along with NAG, which indicates both glomerular and tubular injuries, is important, and that renal tubular injury occurs in patients with mild preeclampsia but it did not cause any changes of serum creatinine.

Keywords:

N-acetyl-β-D-glucosaminidase, mild preeclampsia, proteinuria,

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